Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Alzheimer's disease-like alterations in peripheral cells from presenilin-1transgenic mice
Autore:
Eckert, A; Schindowski, K; Leutner, S; Luckhaus, C; Touchet, N; Czech, C; Muller, WE;
Indirizzi:
Univ Frankfurt, Dept Pharmacol, Bioctr, D-60439 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60439 ctr, D-60439 Frankfurt, Germany Aventis Pharma, Res & Dev, F-94403 Vitry, France Aventis Pharma Vitry France F-94403 ma, Res & Dev, F-94403 Vitry, France
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 2, volume: 8, anno: 2001,
pagine: 331 - 342
SICI:
0969-9961(200104)8:2<331:ADAIPC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID BETA-PROTEIN; KNOCK-IN MICE; HIPPOCAMPAL-NEURONS; INCREASED VULNERABILITY; CALCIUM RESPONSES; INDUCED APOPTOSIS; APP MUTATIONS; T-LYMPHOCYTES; FIBROBLASTS; MITOCHONDRIA;
Keywords:
Alzheimer's disease; presenilin-1; cell death; calcium; oxidative stress; lymphocytes; cytochrome c;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Eckert, A Univ Frankfurt, Dept Pharmacol, Bioctr, Marie Curie Str 9, D-60439 Frankfurt, Germany Univ Frankfurt Marie Curie Str 9 Frankfurt Germany D-60439 many
Citazione:
A. Eckert et al., "Alzheimer's disease-like alterations in peripheral cells from presenilin-1transgenic mice", NEUROBIOL D, 8(2), 2001, pp. 331-342

Abstract

Many cases of early-onset inherited Alzheimer's disease (AD) are caused bymutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell death. Interestingly, enhanced vulnerability to cell death has also been demonstrated for peripheral lymphocytes from AD patients. We now report that lymphocytes from PS1 mutant transgenic mice showa similar hypersensitivity to cell death as do peripheral cells from AD patients and several cell culture systems expressing PS1 mutations. The cell death-enhancing action of mutant PS1 was associated with increased production of reactive oxygen species and altered calcium regulation, but not with changes of mitochondrial cytochrome c. Our study further emphasizes the pathogenic role of mutant PS1 and may provide the fundamental basis for new efforts to close the gap between studies using neuronal cell lines transfected with mutant PS1, neurons from transgenic animals, and peripheral cells from AD patients. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:14:05