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Titolo:
The protein 4.1 tumor suppressor, DAL-1, impairs cell motility, but regulates proliferation in a cell-type-specific fashion
Autore:
Gutmann, DH; Hirbe, AC; Huang, ZY; Haipek, CA;
Indirizzi:
Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Neurol, St Louis, MO 63110 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 2, volume: 8, anno: 2001,
pagine: 266 - 278
SICI:
0969-9961(200104)8:2<266:TP4TSD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERM FAMILY MEMBERS; NF2 GENE; NEUROFIBROMATOSIS TYPE-2; SPORADIC MENINGIOMAS; VESTIBULAR SCHWANNOMAS; LUNG-CANCER; MERLIN; EXPRESSION; ADHESION; PRODUCT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Gutmann, DH Washington Univ, Sch Med, Dept Neurol, Box 8111,660 S Euclid Ave, St Louis, MO 63110 USA Washington Univ Box 8111,660 S Euclid Ave St Louis MO USA 63110
Citazione:
D.H. Gutmann et al., "The protein 4.1 tumor suppressor, DAL-1, impairs cell motility, but regulates proliferation in a cell-type-specific fashion", NEUROBIOL D, 8(2), 2001, pp. 266-278

Abstract

The neurofibromatosis 2 (NF2) tumor suppressor belongs to the Protein 4.1 family of molecules that link the actin cytoskeleton to cell surface glycoproteins. We have previously demonstrated that the NF2 protein, merlin, can suppress cell growth in vitro and in vivo as well as impair actin cytoskeleton-associated processes, such as cell spreading, attachment, and motility. Recently, we determined that expression of a second Protein 4.1 tumor suppressor, DAL-1, was lost in 60% of sporadic meningiomas, but not schwannomas. In this report, we demonstrate that DAL-1 suppresses cell proliferation in meningioma, but not schwannoma cells. Similar to merlin, DAL-1 interacts with other ERM proteins and pll-spectrin, but not the merlin interactor protein, SCHIP-1. In addition, we report the identification of the full-lengthDAL-1 tumor suppressor, termed KIAA0987. Collectively, these results suggest that the two Protein 4.1 meningioma tumor suppressors, merlin and DAL-1,may be functionally distinct proteins with different mechanisms of action. (C) 2001 Academic press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:20:14