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Titolo:
Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with down syndrome
Autore:
Head, E; Azizeh, BY; Lott, IT; Tenner, AJ; Cotman, CW; Cribbs, DH;
Indirizzi:
Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ng & Dementia, Irvine, CA 92697 USA Univ Calif Irvine, Mental Retardat Ctr, Dept Pediat, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 , Dept Pediat, Irvine, CA 92697 USA Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 iol & Biochem, Irvine, CA 92697 USA
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 2, volume: 8, anno: 2001,
pagine: 252 - 265
SICI:
0969-9961(200104)8:2<252:CAWNAB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL TEMPORAL-LOBE; ALZHEIMERS-DISEASE; SENILE PLAQUES; A-BETA; NEUROPATHOLOGICAL CHANGES; ANTIINFLAMMATORY AGENTS; ACTIVATED MICROGLIA; PROTEIN; EXPRESSION; C1Q;
Keywords:
Alzheimer's disease; beta-amyloid; C1q; complement; microglia; neuroinflammation; senile plaques; trisomy 21;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Head, E Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 entia, Irvine, CA 92697 USA
Citazione:
E. Head et al., "Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with down syndrome", NEUROBIOL D, 8(2), 2001, pp. 252-265

Abstract

To study the link between beta -amyloid (A beta) and neuroinflammation, weexamined the levels of complement as a function of age and extent of AP deposition in Down Syndrome (DS) brain. C1q, the first component of the complement cascade, was visualized using immunohistochemistry in the frontal, entorhinal cortex, and hippocampus of 12 DS ranging from 31 to 69 years of age. C1q was consistently associated with thioflavine-S positive A beta plaques in DS brain and increased with more extensive age-dependent. A beta deposition. In contrast, little or no C1q labeling was associated with diffuse or thiofiavine-S negative A beta deposits. Neurons in the hippocampus and entorhinal cortex, but less frequently in frontal cortex, were C1q positive in DS cases with sufficient neuropathology to have a diagnosis of Alzheimer's disease. C1q-positive neurons were associated with activated microglia. These results provide evidence for A beta -mediated inflammatory factors contributing to the rapid accumulation of neuropathology in DS brain. (C) 2001 Academic Press.

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Documento generato il 04/04/20 alle ore 11:41:25