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Titolo:
BDNF controls dopamine D-3 receptor expression and triggers behavioural sensitization
Autore:
Guillin, O; Diaz, J; Carroll, P; Griffon, N; Schwartz, JC; Sokoloff, P;
Indirizzi:
Ctr Paul Broca, INSERM, U109, Unite Neurobiol & Pharmacol Mol, F-75014 Paris, France Ctr Paul Broca Paris France F-75014 Pharmacol Mol, F-75014 Paris, France Univ Paris 05, Physiol Lab, F-75006 Paris, France Univ Paris 05 Paris France F-75006 5, Physiol Lab, F-75006 Paris, France INSERM, U382, IBDM, Unite Dev & Pathol Motoneurone Spinal, F-13288 Marseille, France INSERM Marseille France F-13288 eurone Spinal, F-13288 Marseille, France
Titolo Testata:
NATURE
fascicolo: 6833, volume: 411, anno: 2001,
pagine: 86 - 89
SICI:
0028-0836(20010503)411:6833<86:BCDDRE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCAINE-SEEKING BEHAVIOR; NEUROTROPHIC FACTOR; ANTEROGRADE TRANSPORT; MESSENGER-RNA; RAT-BRAIN; AXONAL-TRANSPORT; NEURONS; LESIONS; SCHIZOPHRENIA; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sokoloff, P Ctr Paul Broca, INSERM, U109, Unite Neurobiol & Pharmacol Mol,2Ter Rue Alesia, F-75014 Paris, France Ctr Paul Broca 2Ter Rue Alesia Paris France F-75014 s, France
Citazione:
O. Guillin et al., "BDNF controls dopamine D-3 receptor expression and triggers behavioural sensitization", NATURE, 411(6833), 2001, pp. 86-89

Abstract

Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a polypeptidic factor initially regarded to be responsible for neuron proliferation, differentiation and survival, through its uptake at nerve terminals and retrograde transport to the cell body(1). A more diverse role for BDNF has emerged progressively from observations showing that it is also transported anterogradely(2,3), is released on neuron depolarization(1), and triggers rapid intracellular signals(4) and action potentials in central neurons(5). Here we report that BDNF elicits long-term neuronal adaptations by controlling the responsiveness of its target neurons to the important neurotransmitter, dopamine. Using lesions and gene-targeted mice lacking BDNF, we show that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D-3 receptor in nucleus accumbens(6-8) both during development and in adulthood. BDNF from corticostriatal neurons(3) also induces behavioural sensitization, by triggering overexpression of the D-3 receptor in striatum of hemiparkinsonian rats(9). Our results suggest that BDNFmay be an important determinant of pathophysiological conditions such as drug addiction(10), schizophrenia(11) or Parkinson's disease(12), in which D-3 receptor expression is abnormal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:15:16