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Titolo:
Role of magnesium in genomic stability
Autore:
Hartwig, A;
Indirizzi:
Univ Karlsruhe, Dept Food Chem & Toxicol, D-76128 Karlsruhe, Germany Univ Karlsruhe Karlsruhe Germany D-76128 col, D-76128 Karlsruhe, Germany
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 475, anno: 2001,
pagine: 113 - 121
SICI:
1386-1964(20010418)475:1-2<113:ROMIGS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE EXCISION-REPAIR; DNA-REPAIR; FLAP ENDONUCLEASE-1; CRYSTAL-STRUCTURE; MISMATCH REPAIR; DAMAGE; CELLS; REPLICATION; DEFICIENCY; RESIDUES;
Keywords:
genomic stability; magnesium; tumorigenesis; dietary intake; oxidative stress;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Hartwig, A Univ Karlsruhe, Dept Food Chem & Toxicol, Prosfach 6980, D-76128 Karlsruhe, Germany Univ Karlsruhe Prosfach 6980 Karlsruhe Germany D-76128 Germany
Citazione:
A. Hartwig, "Role of magnesium in genomic stability", MUT RES-F M, 475(1-2), 2001, pp. 113-121

Abstract

In cellular systems, magnesium is the second most abundant element and is involved in basically ah metabolic pathways. At physiologically relevant concentrations, magnesium itself is not genotoxic, but is highly required to maintain genomic stability. Besides its stabilizing effect on DNA and chromatin structure, magnesium is an essential cofactor in almost all enzymatic systems involved in DNA processing. Most obvious in studies on DNA replication, its function is not only charge-related, but very specific with respect to the high fidelity of DNA synthesis. Furthermore, as essential cofactorin nucleotide exercision repair, base excision repair and mismatch repair magnesium is required for the removal of DNA damage generated by environmental mutagens, endogenous processes, and DNA replication. Intracellular magnesium concentrations are highly regulated and magnesium acts as an intracellular regulator of cell cycle control and apoptosis. As evident from animalexperiments and epidemiological studies, magnesium deficiency may decreasemembrane integrity and membrane function and increase the susceptibility to oxidative stress, cardiovascular heart diseases as well as accelerated aging. The relationship to tumor formation is more complex; magnesium appearsto be protective at early stages but promotes the growth of existing tumors. With respect to the magnesium status in humans, the daily intake in mostindustrialized countries does not reach the current recommended daily dietary allowances (RDA) values, and thus marginal magnesium deficiencies are very common. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:23:50