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Titolo:
Vitamin E and genome stability
Autore:
Claycombe, KJ; Meydani, SN;
Indirizzi:
Tufts Univ, USDA, Jean Mayer Human Nutr Res Ctr, Nutrit Immunol Lab, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 , Nutrit Immunol Lab, Boston, MA 02111 USA
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 475, anno: 2001,
pagine: 37 - 44
SICI:
1386-1964(20010418)475:1-2<37:VEAGS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE DNA-DAMAGE; SINGLE-STRAND BREAKS; PERIPHERAL-BLOOD LYMPHOCYTES; INDUCED CHROMOSOMAL DAMAGE; HUMAN ENDOTHELIAL-CELLS; TRANSGENIC MOUSE MODEL; ALPHA-TOCOPHEROL; CIGARETTE-SMOKE; NITRIC-OXIDE; INDUCED APOPTOSIS;
Keywords:
Vitamin E; DNA damage; genome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Meydani, SN Tufts Univ, USDA, Jean Mayer Human Nutr Res Ctr, Nutrit Immunol Lab, 711 Washington St, Boston, MA 02111 USA Tufts Univ 711 Washington StBoston MA USA 02111 MA 02111 USA
Citazione:
K.J. Claycombe e S.N. Meydani, "Vitamin E and genome stability", MUT RES-F M, 475(1-2), 2001, pp. 37-44

Abstract

Free radicals and reactive oxygen species (ROS) which are generated continuously cause mutagenic alterations resulting in cancer, aging and abnormalities in the nervous system. Accumulating evidence indicates that Vitamin E,the most potent lipid peroxyl radical scavenger, may reduce free radical induced chromosomal damages through inhibition of free radical formation, and activation of endonuclease that can be triggered by intracellular oxidative stress, and by increasing the rate of removal of damaged DNA. Although some studies suggest a potential usefulness of Vitamin E in the prevention of mutagenic effects caused by genotoxic free radicals, other studies reportno effects. Thus the data are not conclusive enough to be used as a basis to change the current recommended dietary allowances (RDA). Future researchshould address molecular mechanisms underlying the protective effects of Vitamin E and develop appropriate biologically relevant biomarkers of DNA damage to further help in determining the dietary levels of Vitamin E needed to protect the genetic pool from internally and esternally induced DNA damages. (C) 2001 Elsevier Science B.V. W lights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:11:23