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Titolo:
Vitamin C and genomic stability
Autore:
Halliwell, B;
Indirizzi:
Natl Univ Singapore, Dept Biochem, Singapore 119260, Singapore Natl Univ Singapore Singapore Singapore 119260 ngapore 119260, Singapore
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 475, anno: 2001,
pagine: 29 - 35
SICI:
1386-1964(20010418)475:1-2<29:VCAGS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE DNA-DAMAGE; ASCORBIC-ACID; IN-VIVO; ENDOTHELIAL DYSFUNCTION; ANTIOXIDANT VITAMINS; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; BRUSSELS-SPROUTS; GENETIC-DAMAGE; URATE OXIDASE;
Keywords:
Vitamin C; DNA damage;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Halliwell, B Natl Univ Singapore, Dept Biochem, 10 Kent Ridge Crescent, Singapore 119260, Singapore Natl Univ Singapore 10 Kent Ridge Crescent Singapore Singapore 119260
Citazione:
B. Halliwell, "Vitamin C and genomic stability", MUT RES-F M, 475(1-2), 2001, pp. 29-35

Abstract

Vitamin C, a water-soluble glucose derivative, has considerable antioxidant activity in vitro, in part because of its ease of oxidation and because the semidehydroascorbate radical derived from it is of low reactivity. Vitamin C in vivo is an essential cofactor for a range of enzymes involved in diverse metabolic pathways, but much recent Literature has focused on its antioxidant effects. Consumption of foods rich in Vitamin C (fruits and vegetables) is associated with decreased risk of cardiovascular disease, of many types of cancer and possibly of neurodegenerative disease, but the extent to which Vitamin C contributes to these effects Is uncertain. Data using biomarkers of oxidative damage to DNA bases have given no compelling evidence to date that ascorbate supplements can decrease the levels of oxidative DNAdamage in vivo, except perhaps in subjects with very low Vitamin C intakes, Similarly: there is no conclusive evidence from studies of strand breaks,micronuclei, or chromosomal aberrations for a protective effect of VitaminC. There is limited evidence that supplements of Vitamin C might have beneficial effects in disorders of vascular function, and that diet-derived Vitamin C may decrease gastric cancer incidence in certain populations, but itis not clear whether it is the antioxidant or other properties of ascorbate that are responsible for these two actions. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:57:04