Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Carotenoids and genomic stability
Autore:
Collins, AR;
Indirizzi:
DNA Instabil Grp, Rowett Res Inst, Aberdeen AB21 9SB, Scotland DNA Instabil Grp Aberdeen Scotland AB21 9SB Aberdeen AB21 9SB, Scotland
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 475, anno: 2001,
pagine: 21 - 28
SICI:
1386-1964(20010418)475:1-2<21:CAGS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE DNA-DAMAGE; BETA-CAROTENE; HUMAN-LYMPHOCYTES; IN-VIVO; CARDIOVASCULAR-DISEASE; ANTIOXIDANT PROPERTIES; LUNG-CANCER; HUMAN-CELLS; VITAMIN-C; SUPPLEMENTATION;
Keywords:
carotenoids; beta-carotene; DNA damage;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Collins, AR DNA Instabil Grp, Rowett Res Inst, Greenburn Rd, Aberdeen AB219SB, Scotland DNA Instabil Grp Greenburn Rd Aberdeen Scotland AB21 9SB land
Citazione:
A.R. Collins, "Carotenoids and genomic stability", MUT RES-F M, 475(1-2), 2001, pp. 21-28

Abstract

Epidemiological evidence abounds for a link between intake of carotenoids from fruit and vegetable foods and relatively low incidence of various cancers. However, intervention trials have shown, in some cases, a significant increase in occurrence of lung cancer in those volunteers taking supplements of beta -carotene. More information is clearly needed about the mechanismof action of carotenoids. Effects of carotenoids on cells in culture include inhibition of DNA synthesis and proliferation, changes in gene expression. decreased micronucleus frequency, and inhibition of transformation via synthesis of gap-junction proteins. Experiments with animal models are unsatisfactory because of the very poor uptake of carotenoids in rodents compared with man. In humans, oxidative damage to lymphocytes correlates negatively with plasma carotenoid concentrations, and the level of DNA damage is susceptible to reduction by carotenoid-rich foods. It seems clear that the carotenoids act as antioxidants in vivo, and vet this activity may not result in cancer prevention. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:36:01