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Titolo:
DNA damage from micronutrient deficiencies is likely to be a major cause of cancer
Autore:
Ames, BN;
Indirizzi:
Univ Calif Berkeley, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 erkeley, Berkeley, CA 94720 USA
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 475, anno: 2001,
pagine: 7 - 20
SICI:
1386-1964(20010418)475:1-2<7:DDFMDI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; RANDOMIZED CONTROLLED TRIAL; POLY(ADP-RIBOSE) POLYMERASE-ACTIVITY; VITAMIN-E SUPPLEMENTATION; UNITED-STATES POPULATION; LOW-INCOME HOUSEHOLDS; PROSTATE-CANCER; ALPHA-TOCOPHEROL; ZINC-DEFICIENCY; RISK FACTOR;
Keywords:
DNA damage; vitamin deficiency; trace mineral deficiency;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
169
Recensione:
Indirizzi per estratti:
Indirizzo: Ames, BN Childrens Hosp ORL, 5700 MLK Way Jr, Oakland, CA 94609 USA Childrens Hosp ORL 5700 MLK Way Jr Oakland CA USA 94609 94609 USA
Citazione:
B.N. Ames, "DNA damage from micronutrient deficiencies is likely to be a major cause of cancer", MUT RES-F M, 475(1-2), 2001, pp. 7-20

Abstract

A deficiency of any of the micronutrients: folic acid, Vitamin B12, Vitamin B6, niacin, Vitamin C, Vitamin E, iron, or zinc, mimics radiation in damaging DNA by causing single- and double-strand break-a, oxidative lesions, or both. For example, the percentage of the US population that has a low intake (< 50% of the RDA) for each of these eight micronutrients ranges from to > 20%. A level of folate deficiency causing chromosome breaks was presentin approximately 10% of the US population, and in a much higher percentageof the poor. Folate deficiency causes extensive incorporation of uracil into human DNA (4 million/cell), leading to chromosomal breaks. This mechanism is the likely cause of the increased colon cancer risk associated with low folate intake. Some evidence, and mechanistic considerations, suggest that Vitamin B12(14% US elderly) and B6 (10% of US) deficiencies also cause high uracil and chromosome breaks. Micronutrient deficiency may explain, in good part, why the quarter of the population that eats the fewest fruits andVegetables (five portions a day is advised) has about double the cancer rate for most types of cancer when compared to the quarter with the highest intake. For example, 80% of American children and adolescents and 68% of adults do not eat five portions a day. Common micronutrient deficiencies are likely to damage DNA by the same mechanism as radiation and many chemicals, appear to be orders of magnitude more important, and should be compared forperspective. Remedying micronutrient deficiencies should lead to a major improvement in health and an increase in longevity at low cost. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/01/20 alle ore 14:28:46