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Titolo:
A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons
Autore:
Sasaki, M; Seo-Kiryu, S; Kato, R; Kita, S; Kiyama, H;
Indirizzi:
Osaka City Univ, Grad Sch Med, Dept Anat, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 Anat, Abeno Ku, Osaka 5458585, Japan Asahikawa Med Coll, Dept Oral & Maxillofacial Surg, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan Asahikawa Med Coll, Dept Anat, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 89, anno: 2001,
pagine: 158 - 163
SICI:
0169-328X(20010418)89:1-2<158:ADAMWT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; I-KAPPA-B; WHITE-MATTER; PROTEIN; KINASE; REGENERATION; PROTEOGLYCAN; NEUROGENESIS; DROSOPHILA; CLONING;
Keywords:
ADAM; metalloprotease; nerve regeneration; IL-1 alpha; neurite outgrowth; axotomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kiyama, H Osaka City Univ, Grad Sch Med, Dept Anat, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahimachi Osaka Japan 5458585 585, Japan
Citazione:
M. Sasaki et al., "A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons", MOL BRAIN R, 89(1-2), 2001, pp. 158-163

Abstract

Following rat hypoglossal nerve injury, expression of mRNAs for a disintegrin and metalloprotease with thrombospondin type 1 motifs (ADAMTS-1) and IL-I receptor type 1 (n-1RT1) are induced in the injured motor neurons. Although N1E-115 (N1E) cells, which were treated with IL-1 alpha. showed no alteration of ADAMTS-1 mRNA expression, a substantial increase of ADAMTS-1 mRNAexpression was observed in the N1E cells expressing IL-1RT1. These findings suggest that nerve injury promotes IL-1RT1 expression in the injured neurons and thereby ADAMTS-1 transcription was induced in response to IL-1 released from glial cells. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:26:48