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Titolo:
Biochemical evidence for localization of AMPA-type glutamate receptor subunits in the dendritic raft
Autore:
Suzuki, T; Ito, J; Takagi, H; Saitoh, F; Nawa, H; Shimizu, H;
Indirizzi:
Shinshu Univ, Sch Med, Res Ctr Aging & Adaptat, Dept Neuroplast, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Nagoya City Univ, Sch Med, Dept Biochem, Mizuho Ku, Nagoya, Aichi 4678601,Japan Nagoya City Univ Nagoya Aichi Japan 4678601 , Nagoya, Aichi 4678601,Japan Niigata Univ, Sch Med, Inst Brain Res, Dept Mol Neurobiol, Niigata 951, Japan Niigata Univ Niigata Japan 951 s, Dept Mol Neurobiol, Niigata 951, Japan Nagoya City Univ, Sch Med, Collaborat Res Ctr, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 89, anno: 2001,
pagine: 20 - 28
SICI:
0169-328X(20010418)89:1-2<20:BEFLOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED HIPPOCAMPAL-NEURONS; ACTIVATED PROTEIN-KINASE; POSTSYNAPTIC DENSITY FRACTIONS; DOMAIN-CONTAINING PROTEIN; RAT-BRAIN; SYNAPTIC TRANSMISSION; SILENT SYNAPSES; SURFACE EXPRESSION; CEREBRAL-CORTEX; NERVOUS-SYSTEM;
Keywords:
postsynaptic density; raft; AMPA-type glutamate receptor; silent synapse; ras/MAP kinase signaling pathway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Shinshu Univ, Sch Med, Res Ctr Aging & Adaptat, Dept Neuroplast,Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 gano 3908621, Japan
Citazione:
T. Suzuki et al., "Biochemical evidence for localization of AMPA-type glutamate receptor subunits in the dendritic raft", MOL BRAIN R, 89(1-2), 2001, pp. 20-28

Abstract

A low density Triton-insoluble fraction with characteristic lipid composition was prepared from synaptic plasma membrane from the rat forebrain. The fraction was named dendritic raft based on its absence of the presynaptic marker synaptophysin, the presence of postsynaptic Glutamate receptor (GluR)subunits, and its resemblance to raft, caveolae-like structure. We found adifferential distribution of NMDA-type and AMPA-type GluR subunits in the dendritic raft and postsynaptic density (PSD) fractions; the latter type GluR subunits were localized to the dendritic raft as well as PSD fraction, whereas the former type was mostly localized to the PSD fraction. We also found the differential distribution of the components of ras/mitogen-activated protein kinase (MAPK pathway to the dendritic raft and PSD fractions. Dendritic raft and PSD may possibly interact at the postsynaptic sites for efficient signal processing that is required for expression of synaptic plasticity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:01:03