Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Application of in vivo microdialysis to the study of cholinergic systems
Autore:
Day, JC; Kornecook, TJ; Quirion, R;
Indirizzi:
McGill Univ, Douglas Hosp Res Ctr, Verdun, PQ H4H 1R3, Canada McGill UnivVerdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ, Dept Psychiat, Verdun, PQ H4H 1R3, Canada McGill Univ VerdunPQ Canada H4H 1R3 Psychiat, Verdun, PQ H4H 1R3, Canada
Titolo Testata:
METHODS
fascicolo: 1, volume: 23, anno: 2001,
pagine: 21 - 39
SICI:
1046-2023(200101)23:1<21:AOIVMT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL ACETYLCHOLINE-RELEASE; FREELY MOVING RATS; PERFORMANCE LIQUID-CHROMATOGRAPHY; PARAFASCICULAR THALAMIC NUCLEUS; BENZODIAZEPINE RECEPTOR LIGANDS; TRAUMATIC BRAIN INJURY; DOPAMINE D1 RECEPTORS; METHYL-D-ASPARTATE; IN-VIVO; HIPPOCAMPAL ACETYLCHOLINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
239
Recensione:
Indirizzi per estratti:
Indirizzo: Day, JC McGill Univ, Douglas Hosp Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 , Verdun, PQ H4H 1R3, Canada
Citazione:
J.C. Day et al., "Application of in vivo microdialysis to the study of cholinergic systems", METHODS, 23(1), 2001, pp. 21-39

Abstract

The application of in vivo microdialysis to the study of acetylcholine (ACh) release has contributed greatly to our understanding of cholinergic brain systems. This article reviews standard experimental procedures for dialysis probe selection and implantation, perfusion parameters, neurochemical detection, and data analysis as they relate to microdialysis assessments of cholinergic function. Particular attention is focused on the unique methodological considerations that arise when in vivo microdialysis is dedicated expressly to the recovery and measurement of ACR as opposed to other neurotransmitters. Limitations of the microdialysis technique are discussed, as well as methodological adaptations that may prove useful in overcoming these limitations. This is followed by an overview of recent studies in which the application of in vivo microdialysis has been used to characterize the basic pharmacology and physiology of cholinergic neurons. Finally, the usefulness of the microdialysis approach for testing hypotheses regarding the cholinergic systems' involvement in cognitive processes is examined. It can be concluded that, in addition to being a versatile and practical method for studying the neurochemistry of cholinergic brain systems, in vivo microdialysis represents a valuable tool in our efforts to better comprehend ACh's underlying role in a variety of behavioral processes. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:46:42