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Titolo:
Severe bone marrow failure associated with the use of alternating steroid with chlorambucil in lupus membranous nephropathy in Chinese
Autore:
Wang, AYM; Li, PKT; Lai, FMM; Chow, KM; Szeto, CC; Leung, CB; Lui, SF;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
LUPUS
fascicolo: 4, volume: 10, anno: 2001,
pagine: 295 - 298
SICI:
0961-2033(2001)10:4<295:SBMFAW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-CENTER; NEPHRITIS; BIOPSY;
Keywords:
lupus; membranous nephropathy; chlorambucil; pancytopenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, AYM Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut,Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China China
Citazione:
A.Y.M. Wang et al., "Severe bone marrow failure associated with the use of alternating steroid with chlorambucil in lupus membranous nephropathy in Chinese", LUPUS, 10(4), 2001, pp. 295-298

Abstract

Severe pancytopenia associated with the use of alternating steroid with chlorambucil regimen was described in six patients with nephrotic syndrome secondary to lupus membranous nephropathy (WHO class V). We believe this is the first report describing the life-threatening degree of marrow toxicity associated with this regimen of alternating steroid with chlorambucil in a Chinese population. Our data suggests that the susceptibility to marrow toxicity with the use of chlorambucil may only be applicable to Chinese patients with underlying systemic lupus erythematosus as a similar degree of toxicity has neither been reported in lupus patients of other ethnic groups nor in non-lupus patients of Chinese origin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:10:16