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Titolo:
Oxidative stress is reduced by the long-term use of vitamin E-coated dialysis filters
Autore:
Satoh, M; Yamasaki, Y; Nagake, Y; Kasahara, J; Hashimoto, M; Nakanishi, N; Makino, H;
Indirizzi:
Okayama Univ, Sch Med, Dept Med 3, Okayame 7008558, Japan Okayama Univ Okayame Japan 7008558 d, Dept Med 3, Okayame 7008558, Japan Fuchu Gen Hosp, Hiroshima Prefectural Welf Federat Agr Cooperat, Hiroshima, Japan Fuchu Gen Hosp Hiroshima Japan f Federat Agr Cooperat, Hiroshima, Japan
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 5, volume: 59, anno: 2001,
pagine: 1943 - 1950
SICI:
0085-2538(200105)59:5<1943:OSIRBT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCATION END-PRODUCTS; OXYGEN SPECIES PRODUCTION; CHRONIC-RENAL-FAILURE; LIPID-PEROXIDATION; DNA-DAMAGE; MAINTENANCE HEMODIALYSIS; MONOCLONAL-ANTIBODY; BIOMARKER EVIDENCE; CROSSOVER TRIAL; FREE-RADICALS;
Keywords:
advanced glycation end-products; malondialdehyde; 8-hydroxydeoxyguanosine; diabetes mellutus; antioxidant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Satoh, M Okayama Univ, Sch Med, Dept Med 3, 2-5-1 Shikata Cho, Okayame 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayame Japan 7008558 8558, Japan
Citazione:
M. Satoh et al., "Oxidative stress is reduced by the long-term use of vitamin E-coated dialysis filters", KIDNEY INT, 59(5), 2001, pp. 1943-1950

Abstract

Background. Oxidative stress during hemodialysis is thought to promote theprogression of vascular complications in hemodialysis patients. The protective role of vitamin E as a lipophilic antioxidant against oxidative stresshas been widely investigated. Here we investigated the effects of a vitamin E-coated regenerated cellulose hollow fiber dialyzer (CL-EE) on oxidativestress compared with a polysulfone hollow fiber (CL-PS). Methods. Far at least three months before beginning the protocol, 10 nondiabetic (NDM) patients (70.0 +/- 7.5 years; 6 males and 4 females) and S diabetic (DM) patients (65.0 +/- 7.4 years; 4 males, 4 females) were dialyzed with CL-PS. After that, we treated all of the patients with CL-EE for six months. Malondialdehyde (MDA) advanced glycation end products (AGEs), and 8-hydroxydeoxyguanosine (8-OHdG) were monitored as biomarkers for oxidative stress at the start and then at one, three, and six months into treatment with CL-EE. Results. Serum MDA, AGE, and 8-OHdG levels increased after the hemodialysis with CL-PS. The increase of the biomarkers was completely prevented by a single use of CL-EE. Long-term hemodialysis with CL-EE for sir; months significantly reduced the basal levels of the oxidant markers at one month for AGE and at six months for 8-OHdG in both DM and NDM patients, Serum MDA wasreduced in only DM patients at three months. The improvement of the oxidative stress with CL-EE was more prominent in the DM patients. Conclusions. Long-term treatment with CL-EE efficiently improves the oxidative stress associated with hemodialysis and potentially reduces dialysis complications due to oxidative stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:41:56