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Titolo:
Differential effects of vascular endothelial growth factor-C and placentalgrowth factor-1 on the hydraulic conductivity of frog mesenteric capillaries
Autore:
Hillman, NJ; Whittles, CE; Pocock, TM; Williams, B; Bates, DO;
Indirizzi:
Univ Bristol, Sch Vet, Dept Physiol, Bristol BS2 8EJ, Avon, England Univ Bristol Bristol Avon England BS2 8EJ Bristol BS2 8EJ, Avon, England Univ Leicester, Cardiovasc Res Inst, Leicester, Leics, England Univ Leicester Leicester Leics England s Inst, Leicester, Leics, England
Titolo Testata:
JOURNAL OF VASCULAR RESEARCH
fascicolo: 2, volume: 38, anno: 2001,
pagine: 176 - 186
SICI:
1018-1172(200103/04)38:2<176:DEOVEG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-AFFINITY BINDING; SIGNAL-TRANSDUCTION; PHOSPHOLIPASE-C; GENE-THERAPY; FACTOR VEGF; PERMEABILITY; RECEPTORS; KINASE; KDR; PROLIFERATION;
Keywords:
vascular permeability; VEGF-C; PIGF; endothelium; hydraulic conductivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bates, DO Univ Bristol, Sch Vet, Dept Physiol, Southwell St, Bristol BS2 8EJ, Avon, England Univ Bristol Southwell St Bristol Avon England BS2 8EJ , England
Citazione:
N.J. Hillman et al., "Differential effects of vascular endothelial growth factor-C and placentalgrowth factor-1 on the hydraulic conductivity of frog mesenteric capillaries", J VASC RES, 38(2), 2001, pp. 176-186

Abstract

Vascular endothelial growth factors (VEGFs) are known to increase vascularpermeability. VEGF-A acts on two receptor tyrosine kinases, VEGF receptor-1 (VEGF-R1 or flt-1) a nd VEGF receptor-2 (VEGF-R2, flk-1 or KDR). VEGF-C acts only on VEGF-R2 on vascular endothelial cells, whereas placental growthfactor-1 (PIGF-1) acts only on VEGF-R1. The effects of perfusion of these receptor-specific proteins on hydraulic conductivity (L-p) was measured in frog mesenteric capillaries. The effect of PIGF on L-p was not conclusive, and overall fluid flux did not increase during that time. VEGF-C acutely and transiently increased L-p (4.5 +/- 0.9-fold), which was more obvious in asubset of vessels, in a similar manner to that reported for VEGF-A. In thesubset of vessels in which VEGF-C significantly increased L-p acutely, there was a sustained 12-fold increase in L-p 20 min after perfusion, but thiswas not seen in those vessels which did not respond acutely to VEGF-C, or in vessels exposed to PIGF-1. L-p was also increased 24 h after perfusion with VEGF-C, but not with PIGF-1. Western blot analysis showed that VEGF-R1 and VEGF-R2 are both present in frog tissue. These data show that the VEGFsthat stimulate VEGF-R2 chronically increase L-p, but not those that stimulate VEGF-R1 only. This supports the hypothesis that chronic increases in microvascular permeability induced by VEGF are mediated via activation of VEGF-R2 rather than VEGF-R1. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 16:24:27