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Titolo:
Bladder dysfunction after acute urinary retention in rats
Autore:
Saito, M; Miyagawa, I;
Indirizzi:
Tottori Univ, Fac Med, Dept Urol, Tottori 680, Japan Tottori Univ Tottori Japan 680 v, Fac Med, Dept Urol, Tottori 680, Japan
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 5, volume: 165, anno: 2001,
pagine: 1745 - 1747
SICI:
0022-5347(200105)165:5<1745:BDAAUR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; ISCHEMIA-REPERFUSION; OUTLET OBSTRUCTION;
Keywords:
bladder; urinary retention; free radicals; carbachol; rats, Wistar;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Saito, M Tottori Univ, Fac Med, Dept Urol, Tottori 680, Japan Tottori Univ Tottori Japan 680 d, Dept Urol, Tottori 680, Japan
Citazione:
M. Saito e I. Miyagawa, "Bladder dysfunction after acute urinary retention in rats", J UROL, 165(5), 2001, pp. 1745-1747

Abstract

Purpose: We investigated bladder function in acute urinary retention and subsequent catheterization in rat bladders. Materials and Methods: The penile urethra in rats was clamped with a smallclip and cystostomy was performed to infuse 3 ml. of saline for inducing acute urinary retention. At 30 minutes after the induction of urinary retention the cystostomy was opened to empty the bladder. In functional studies contractile responses to carbachol were measured in group 1-before, group 2-at 3 ml. of urinary retention, group 3-at 3 ml. of urinary retention exposed for 30 minutes and group 4-30 minutes after catheterization. Moreover, invivo real-time monitoring of blood flow and vesical pressure were measuredin the bladders With a laser Doppler flowmeter and cystometrography, respectively. Malonaldehyde and 4-hydroxyalkenals were measured by colorimetric assay in these groups. Results: In functional studies the mean maximum contractile response valueplus or minus standard deviation of carbachol-to-bladder in groups 1 to 4 was 11.8 +/- 1.3, 11.9 +/- 1.7, 9.8 +/- 0.8 and 6.9 +/- 0.7 gm./mm.(2), respectively. In real-time monitoring of blood flow and vesical pressure acuteurinary retention significantly decreased blood flow and increased vesicalpressure, and subsequent catheterization increased blood flow and decreased vesical pressure in the bladders. The concentrations of malonaldehyde and4-hydroxyalkenals in the bladders in group 4 were significantly higher than in the other groups. Conclusions: Our data indicate that bladder dysfunction after catheterization is partially caused by free radicals, which have an important role in bladder dysfunction during acute urinary retention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 07:01:26