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Titolo:
Optimal combinations of systematic sextant and laterally directed biopsiesfor detection of prostate cancer
Autore:
Gore, JL; Shariat, SF; Miles, BJ; Kadmon, D; Jiang, N; Wheeler, TM; Slawin, KM;
Indirizzi:
Baylor Coll Med, Scott Dept Urol, Matsunaga Conte Prostate Canc Res Ctr, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Canc Res Ctr, Houston, TX 77030 USA Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pathol, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 5, volume: 165, anno: 2001,
pagine: 1554 - 1559
SICI:
0022-5347(200105)165:5<1554:OCOSSA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORE BIOPSIES; PROTOCOL; TRIAL;
Keywords:
prostatic neoplasms; biopsy; prostate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Gore, JL Baylor Coll Med, Scott Dept Urol, Matsunaga Conte Prostate Canc Res Ctr, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Ctr, Houston, TX 77030 USA
Citazione:
J.L. Gore et al., "Optimal combinations of systematic sextant and laterally directed biopsiesfor detection of prostate cancer", J UROL, 165(5), 2001, pp. 1554-1559

Abstract

Purpose: The standard sextant protocol for obtaining transrectal ultrasound guided biopsy of the prostate has been shown to underestimate the presence of prostate cancer. Studies have demonstrated an increased cancer detection rate with additional laterally directed biopsies. We compared the sensitivity of individual biopsy cares and evaluated combinations of these cores to identify an optimal biopsy strategy. Materials and Methods: A total of 396 consecutive patients underwent biopsy of the lateral peripheral zone in addition to standard sextant biopsy. The cancer detection rate for each biopsy core was calculated. The sensitivity of different combinations of biopsy cores was compared with those of standard sextant biopsies and with a 12 core biopsy protocol that combined the standard sextant biopsy with a complete set of laterally directed cores. Results: Cancer was detected in 160 of 396 (40.3%) patients. Of the possible combinations of biopsy cores a strategy that included laterally directedcores at the base, mid gland and apex of the prostate with mid lobar base and apical cores detected 98.5% of cancers. The detection rate of this 10 core biopsy regimen was significantly better than that of the standard sextant protocol (p less than or equal to 0.001), and was equivalent to that of the 12 core regional biopsy (p greater than or equal to0.302). Conclusions: The standard sextant protocol failed to detect a large proportion of cancers located laterally in the peripheral zone. A 10 core biopsy regimen that combined laterally directed cores at the base, mid gland and apex of the prostate with mid lobar biopsy cores at the base and apex maximizes the sensitivity of transrectal ultrasound guided systematic biopsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 18:03:36