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Titolo:
E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term followup
Autore:
Byrne, RA; Shariat, SF; Brown, R; Kattan, MW; Morton, RA; Wheeler, TM; Lerner, SP;
Indirizzi:
Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ott Dept Urol, Houston, TX 77030 USA Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pathol, Houston, TX 77030 USA Methodist Hosp, Houston, TX 77030 USA Methodist Hosp Houston TX USA 77030Methodist Hosp, Houston, TX 77030 USA Mem Sloan Kettering Canc Ctr, Dept Urol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Biostat, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 5, volume: 165, anno: 2001,
pagine: 1473 - 1479
SICI:
0022-5347(200105)165:5<1473:EIOBTC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULE; POOR SURVIVAL; EXPRESSION; CANCER; TUMORS; DEDIFFERENTIATION; IMMUNOREACTIVITY; GRADE;
Keywords:
carcinoma, transitional cell; carcinoma in situ; lymph nodes; cadherins; neoplasm metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Byrne, RA Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 rol, Houston, TX 77030 USA
Citazione:
R.A. Byrne et al., "E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term followup", J UROL, 165(5), 2001, pp. 1473-1479

Abstract

Purpose: We analyze the expression of E-cadherin in bladder transitional cell carcinoma, areas of carcinoma in situ and lymph node metastases, and determine the value of E-cadherin immunoreactivity for predicting disease progression and survival of patients with bladder transitional cell carcinoma. Materials and Methods: The study group consisted of 77 patients who underwent radical cystectomy. Formalin fixed paraffin sections were processed with a hot, citric acid antigen retrieval method, followed by immunostaining with anti-E-cadherin monoclonal antibody and a standard avidin biotin complex technique. E-cadherin expression was also evaluated in carcinoma in situ sections (18) and in regional lymph node metastases (17). Results: Loss of normal membrane E-cadherin immunoreactivity was found in 59 (77%) patients. Abnormal expression of E-cadherin was associated with muscle invasive disease (p = 0.010) and lymph node metastasis (p = 0.044). Ofthe 18 carcinoma in situ specimens 15 (83%) and of the 17 metastatic lymphnodes 13 (76%) had abnormal E-cadherin expression. Concordance rates of E-cadherin status in carcinoma in situ areas and metastatic lymph nodes with the primary tumors were 85% and 88%, respectively. At a median followup of 128 months, abnormal E-cadherin expression was significantly associated with disease progression (p = 0.0219) and bladder cancer specific survival (p = 0.037). E-cadherin expression and pathological stage but not grade were independent predictors of disease progression (p = 0.042, 0.047 and 0.158, respectively). Conclusions: In bladder cancer alter ed E-cadherin expression is associated with the degree of invasiveness, lymph node metastasis and increased riskof death from bladder cancer. Furthermore, E-cadherin status is an independent predictor of disease progression in patients treated with cystectomy for transitional cell carcinoma of the bladder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:14:40