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Titolo:
Some cardiopulmonary effects of midazolam premedication in clenbuterol-treated bitches during surgical endoscopic examination of the uterus and ovariohysterectomy
Autore:
Stegmann, GF; Bester, L;
Indirizzi:
Univ Pretoria, Fac Vet Sci, Dept Compan Anim Surg, ZA-0110 Onderstepoort, South Africa Univ Pretoria Onderstepoort South Africa ZA-0110 rstepoort, South Africa
Titolo Testata:
JOURNAL OF THE SOUTH AFRICAN VETERINARY ASSOCIATION-TYDSKRIF VAN DIE SUID-AFRIKAANSE VETERINERE VERENIGING
fascicolo: 1, volume: 72, anno: 2001,
pagine: 33 - 36
SICI:
1019-9128(200103)72:1<33:SCEOMP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASODILATION; COMBINATION; MECHANISMS;
Keywords:
anaesthesia; canine; cardiopulmonary; clenbuterol; midazolam; propofol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Stegmann, GF Univ Pretoria, Fac Vet Sci, Dept Compan Anim Surg, Private Bag X04, ZA-0110 Onderstepoort, South Africa Univ Pretoria Private Bag X04 Onderstepoort South Africa ZA-0110
Citazione:
G.F. Stegmann e L. Bester, "Some cardiopulmonary effects of midazolam premedication in clenbuterol-treated bitches during surgical endoscopic examination of the uterus and ovariohysterectomy", J SA VET AS, 72(1), 2001, pp. 33-36

Abstract

Midazolam was administered intravenously to 8 bitches in a randomised, placebo-controlled clinical trial before propafol induction of surgical anaesthesia. Anaesthesia was maintained with isoflurane-in-oxygen during surgicalendoscopic examination of the uterus and ovariohysterectomy. Clenbuterol was administered at the start of surgery to improve uterine muscle relaxation, and to facilitate endoscopic examination of the uterus. Ventilation was controlled. Induction of anaesthesia with propofol to obtain loss of the pedal reflex resulted in a statistically significant (P < 0.05) decrease in minute volume and arterial oxygen partial pressure in the midazolam group. Apnoea also occurred in 50 % of dogs in the midazolam group. The dose fur propofol in the midazolam group was 7.3 mg/kg compared to 9.5 mg/kg in the control. Minute volume was significantly (P < 0.05) higher in both groups during isoflurane maintenance, compared to the value after incremental propofol to obtain loss of the pedal reflex. Propofol induction resulted in a 25-26 % reduction in the mean arterial blood pressure in both groups, and the administration of clenbuterol at the start of surgery resulted in a transient, but statistically significant (P < 0.05), decrease in mean arterial blood pressure in the midazolam group during isoflurane anaesthesia. It is concluded that intravenous midazolam premedication did not adversely affect cardiovascular function during propofol induction, but intra-operative clenbuterol during isoflurane maintenance of anaesthesia may result in transient hypotension. Midazolam premedication may increase adverse respiratory effects when administered before propofol induction of anaesthesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:11:16