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Titolo:
Sertraline in children and adolescents with social anxiety disorder: An open trial
Autore:
Compton, SN; Grant, PJ; Chrisman, AK; Gammon, PJ; Brown, VL; March, JS;
Indirizzi:
Duke Univ, Med Ctr, Dept Psychiat, Program Child & Adolescent Anxiety Disorders, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 ent Anxiety Disorders, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
fascicolo: 5, volume: 40, anno: 2001,
pagine: 564 - 571
SICI:
0890-8567(200105)40:5<564:SICAAW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; RANDOMIZED CONTROLLED TRIAL; DOUBLE-BLIND; PANIC DISORDER; PHOBIA; FLUOXETINE; DEPRESSION; CHILDHOOD; AMITRIPTYLINE; INVENTORY;
Keywords:
preadolescent; adolescent; social anxiety disorder; sertraline; pharmacotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Compton, SN Duke Univ, Med Ctr, Dept Psychiat, Program Child & Adolescent Anxiety Disorders, Box 3454, Durham, NC 27710 USA Duke Univ Box 3454 DurhamNC USA 27710 4, Durham, NC 27710 USA
Citazione:
S.N. Compton et al., "Sertraline in children and adolescents with social anxiety disorder: An open trial", J AM A CHIL, 40(5), 2001, pp. 564-571

Abstract

Objective: The aim of this open-label study was to assess the therapeutic benefits, response pattern, and safety of sertraline in children with social anxiety disorder. Method: Fourteen outpatient subjects with a primary Axis I diagnosis of social anxiety disorder were treated in an 8-week open trial of sertraline. Diagnostic and primary outcome measures included the Anxiety Disorders interview Schedule for Children, Clinical Global Impressions scale (CGI), Social Phobia and Anxiety Inventory for Children, and a standardized behavioral avoidance test. Results: As measured by the CGI (Improvement sub-Scale), 36% (5/14) of subjects were classified as treatment responders and 29% (4/14) as partial responders by the end of the 8-week trial. A significant clinical response appeared by week 6. Self-report and behavioral measures showed significant clinical improvement into normal range acrossall domains measured. The mean dose of sertraline was 123.21 +/- 37.29 mg per day. Sertraline was generally well tolerated. Conclusion: in open treatment, sertraline resulted in significant improvement in symptoms of childhood social anxiety disorder. Absolute response rates varied depending on rating scales used. Findings from this study are sufficiently strong to warrant a future multisite, randomized, double-blind placebo-controlled of sertraline for treatment of childhood social anxiety disorder.

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Documento generato il 22/01/20 alle ore 12:41:35