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Titolo:
Endogenous rhythms of melatonin, total antioxidant status and superoxide dismutase activity in several tissues of chick and their inhibition by light
Autore:
Albarran, MT; Lopez-Burillo, S; Pablos, MI; Reiter, RJ; Agapito, MT;
Indirizzi:
Univ Valladolid, Fac Sci, Dept Biochem & Mol Biol & Physiol, E-47005 Valladolid, Spain Univ Valladolid Valladolid Spain E-47005 siol, E-47005 Valladolid, Spain Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 truct Biol, San Antonio, TX 78284 USA
Titolo Testata:
JOURNAL OF PINEAL RESEARCH
fascicolo: 4, volume: 30, anno: 2001,
pagine: 227 - 233
SICI:
0742-3098(200105)30:4<227:EROMTA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-PEROXIDASE ACTIVITY; RAT-BRAIN; LIPID-PEROXIDATION; CARCINOGEN SAFROLE; GENE-EXPRESSION; IN-VIVO; DAMAGE; SPLEEN; LYMPHOCYTES; REDUCTASE;
Keywords:
chicks; circadian rhythms; melatonin; superoxide dismutase (SOD); total antioxidant status (TAS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Agapito, MT Univ Valladolid, Fac Sci, Dept Biochem & Mol Biol & Physiol, CPrado Magdalena S-N, E-47005 Valladolid, Spain Univ Valladolid C Prado Magdalena S-N Valladolid Spain E-47005
Citazione:
M.T. Albarran et al., "Endogenous rhythms of melatonin, total antioxidant status and superoxide dismutase activity in several tissues of chick and their inhibition by light", J PINEAL R, 30(4), 2001, pp. 227-233

Abstract

Melatonin was recently shown to be a component of the antioxidative defense system of organisms due to its free radical scavenging ability and to itscapacity to stimulate several antioxidant enzymes. In this report, we studied the endogenous rhythm of the antioxidant enzyme superoxide dismutase (SOD) in three different tissues (cerebral cortex, liver and lung) of chick (Gallus domesticus) (three weeks, at age and sacrificed every 2 hr). During the study the chicks were under a light:dark cycle of 12:12. Total antioxidant status of the plasma was correlated with physiological blood melatonin concentrations. Superoxide dismutase activity exhibited a marked 24 hr rhythm in cerebral cortex. lung and liver, with peak activity coincident with the melatonin and total antioxidant status peaks. The exposure of chicks to constant light for 7 days eliminated the melatonin rhythm as well as the peaks in superoxide dismutase activity and the total antioxidant status. These findings suggest that the melatonin rhythm may be related to the nighttime increase in the superoxide dismutase activity and to total antioxidant capacity of the blood.

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Documento generato il 27/09/20 alle ore 07:09:52