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Titolo:
Direct and indirect methods used to study arterial blood pressure
Autore:
Van Vliet, BN; Chafe, LL; Antic, V; Schnyder-Candrian, S; Montani, JP;
Indirizzi:
Mem Univ Newfoundland, Fac Med, Div Basic Sci, St Johns, NF A1B 3V6, Canada Mem Univ Newfoundland St Johns NF Canada A1B 3V6 ohns, NF A1B 3V6, Canada Univ Fribourg, Inst Physiol, CH-1750 Fribourg, Switzerland Univ Fribourg Fribourg Switzerland CH-1750 CH-1750 Fribourg, Switzerland
Titolo Testata:
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
fascicolo: 2, volume: 44, anno: 2000,
pagine: 361 - 373
SICI:
1056-8719(200009/10)44:2<361:DAIMUT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR PRESSURE; HEART-RATE; DENERVATED RATS; MOVING RATS; MICE; TERM; VARIABILITY; TELEMETRY; RADIOTELEMETRY; HYPERTENSION;
Keywords:
blood pressure measurement; blood pressure telemetry; telemeter; mouse; rat; rabbit; method; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Van Vliet, BN Mem Univ Newfoundland, Fac Med, Div Basic Sci, St Johns, NF A1B 3V6, Canada Mem Univ Newfoundland St Johns NF Canada A1B 3V6 V6, Canada
Citazione:
B.N. Van Vliet et al., "Direct and indirect methods used to study arterial blood pressure", J PHARM TOX, 44(2), 2000, pp. 361-373

Abstract

A number of different approaches exist for assessing blood pressure in experimental animals. Here, we briefly consider the traditional indirect (rodent tail-cuff) and direct (saline-filled catheter) methods of blood pressuremeasurement before going on to describe our experience with blood pressuretelemetry in rabbits, rats. and mice. Blood pressure telemetry offers the ability to obtain a high-fidelity recording of blood pressure continuously,for relatively Long periods of time, in conscious, freely moving animals, without the limitations of restraint or anaesthesia. Since some drift in telemeter offset and sensitivity are inevitable, recalibration of the telemeter devices immediately before implantation and following explantation is essential to ensure and document the accuracy of the blood pressure measurements. For long-term implantations, verification of the calibration can be performed in vivo. at least in the case of large animals, such as rabbits. Telemetry devices suitable for small animals, such as mice, are also available now which will facilitate the accurate characterization of blood pressurein transgenic animals. Telemeter implantation methods in mice are presently difficult, with relatively low success rates being reported. However validation of new methods, such as the insertion of the catheter tip via the carotid artery. may make the technique more widely accessible in the near future.;(C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:00:56