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Titolo:
Chronic blockade of angiotensin II action prevents glomerulosclerosis, butinduces graft vasculopathy in experimental kidney transplantation
Autore:
Smit-van Oosten, A; Navis, G; Stegeman, CA; Joles, JA; Klok, PA; Kuipers, F; Tiebosch, ATMG; van Goor, H;
Indirizzi:
Univ Groningen Hosp, Dept Pathol & Lab Med, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Dept Nephrol, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands phrol, Groningen, Netherlands Univ Utrecht Hosp, Dept Hypertens & Nephrol, Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands s & Nephrol, Utrecht, Netherlands Univ Groningen Hosp, Dept Pediat, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands ediat, Groningen, Netherlands
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 1, volume: 194, anno: 2001,
pagine: 122 - 129
SICI:
0022-3417(200105)194:1<122:CBOAIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITION; CHRONIC ALLOGRAFT NEPHROPATHY; RENAL-TRANSPLANTATION; ARTERIAL-WALL; RAT; REJECTION; INJURY; DISEASE; CELLS; CILAZAPRIL;
Keywords:
kidney; transplantation; ACE; chronic renal failure; rat; renin-angiotensin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Smit-van Oosten, A Univ Groningen Hosp, Dept Pathol & Lab Med, POB 30-001,NL-9700 RB Groningen, Netherlands Univ Groningen Hosp POB 30-001 Groningen Netherlands NL-9700 RB
Citazione:
A. Smit-van Oosten et al., "Chronic blockade of angiotensin II action prevents glomerulosclerosis, butinduces graft vasculopathy in experimental kidney transplantation", J PATHOLOGY, 194(1), 2001, pp. 122-129

Abstract

Long-term renin-angiotensin system blockade is beneficial in a variety of renal diseases, This study examines the long-term (34 weeks) effects of theangiotensin-converting enzyme inhibitor lisinopril and the angiotensin II receptor type I blocker L158,809 in the Fisher to Lewis rat model of chronic renal transplant failure, Treatment in allografted rats with lisinopril or L158,809 was initiated 10 days after transplantation, or at the time whenproteinuria exceeded 50 mg/24 h, Untreated allografts and syngrafts servedas controls, In contrast to syngrafts, untreated allografts developed proteinuria, hypercholesterolaemia, interstitial damage, and glomerulosclerosis, Lisinopril or L158,809 treatment in allografts starting at day 10 after transplantation completely prevented this with the exception of interstitialdamage, but this treatment also caused a reduction in blood pressure and renal function. Moreover, the intimal surface area of the renal arteries wasdramatically increased in allografts treated with either lisinopril or L158,809 compared with untreated allografted rats, Treatment once proteinuria had developed was less effective in preventing glomerulosclerosis, but alsocaused less intimal expansion. Thus, chronic renin-angiotensin system blockade preserves glomerular morphology in the absence of proteinuria, but enhances intimal hyperplasia and reduces renal function in experimental transplantation. In view of these results, it should be questioned whether such treatment benefits renal transplant patients in the long term. Copyright (C)2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:59:13