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Titolo:
Expression of c-fos, heat shock protein 70, neurotrophins, and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate
Autore:
Kinoshita, Y; Ueyama, T; Senba, E; Terada, T; Nakai, K; Itakura, T;
Indirizzi:
Wakayama Med Univ, Dept Anat & Cell Biol, Wakayama 6418509, Japan WakayamaMed Univ Wakayama Japan 6418509 l Biol, Wakayama 6418509, Japan Wakayama Med Univ, Dept Neurol Surg, Wakayama 6418509, Japan Wakayama Med Univ Wakayama Japan 6418509 l Surg, Wakayama 6418509, Japan Wakayama Med Univ, Dept Anat & Neurobiol, Wakayama 6418509, Japan WakayamaMed Univ Wakayama Japan 6418509 robiol, Wakayama 6418509, Japan
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 4, volume: 18, anno: 2001,
pagine: 435 - 445
SICI:
0897-7151(200104)18:4<435:EOCHSP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; CORTICAL SPREADING DEPRESSION; TRANSIENT FOREBRAIN ISCHEMIA; IN-SITU HYBRIDIZATION; METHYL-D-ASPARTATE; ARTERY OCCLUSION; MESSENGER-RNA; MOLECULAR CHAPERONES; TEMPORAL THRESHOLDS; GENE-EXPRESSION;
Keywords:
brain-derived neurotrophic factor; cerebral ischemia; c-fos; COX-2; HSP70; magnesium; penumbra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Ueyama, T Wakayama Med Univ, Dept Anat & Cell Biol, 811-1 Kimiidera, Wakayama 6418509, Japan Wakayama Med Univ 811-1 Kimiidera Wakayama Japan 6418509 Japan
Citazione:
Y. Kinoshita et al., "Expression of c-fos, heat shock protein 70, neurotrophins, and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate", J NEUROTRAU, 18(4), 2001, pp. 435-445

Abstract

The marginal area surrounding a region of ischemic brain tissue, designated as the penumbra, is of interest as a potential area for the rescue of neurons from cell death. Despite its clinical importance, relatively little isknown about the molecular events leading to changes in brain cells in the penumbra following ischemia, In the first part of this study, we used in situ hybridization to investigate the temporal and spatial expression of c-fos, heat shock protein 70 (HSP70), neurotrophins and inducible cyclooxygenase-2 (COX-2) in the rat brain following a 2-h occlusion of the middle cerebral artery (MCA) with reperfusion, In the penumbra and surrounding cortex, upregulation of c-fos, brain-derived neurotrophic factor (BDNF), and COX-2 mRNAs was observed, while expression of HSP70 mRNA was restricted to the penumbra, This spatial discrepancy of mRNA expression suggests that different mechanisms are involved in the regulation of c-fos/BDNF/COX-2 and HSP70 expression, Intravenous infusion of magnesium sulfate (25 mg/kg) decreased both the infarct volume and upregulation of these mRNAs, suggesting its therapeutic potential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:42:25