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Titolo:
Dementia as a complication of schizophrenia
Autore:
de Vries, PJ; Honer, WG; Kemp, PM; McKenna, PJ;
Indirizzi:
Fulbourne Hosp, Cambridge CB1 5EF, England Fulbourne Hosp Cambridge England CB1 5EF osp, Cambridge CB1 5EF, England Univ Cambridge, Dept Psychiat, Dev Psychiat Sect, Cambridge, England Univ Cambridge Cambridge England Dev Psychiat Sect, Cambridge, England Univ British Columbia, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada Southampton Gen Hosp, Dept Nucl Med, Southampton SO9 4XY, Hants, England Southampton Gen Hosp Southampton Hants England SO9 4XY XY, Hants, England
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 5, volume: 70, anno: 2001,
pagine: 588 - 596
SICI:
0022-3050(200105)70:5<588:DAACOS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE ATROPHY; CARD SORTING TEST; AGE DISORIENTATION; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; VENTRICULAR ENLARGEMENT; NEGATIVE SYMPTOMS; ELDERLY PATIENTS; NORMATIVE DATA; TOMOGRAPHY;
Keywords:
schizophrenia; dementia; cognition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: McKenna, PJ Fulbourne Hosp, Cambridge CB1 5EF, England Fulbourne Hosp Cambridge England CB1 5EF ge CB1 5EF, England
Citazione:
P.J. de Vries et al., "Dementia as a complication of schizophrenia", J NE NE PSY, 70(5), 2001, pp. 588-596

Abstract

Objectives-Cognitive impairment is known to occur in schizophrenia, and may be marked in institutionalised patients. The aim of this study was to determine whether it ever warrants an additional diagnosis of dementia. Methods-A population of chronic schizophrenic patients who were aged 65 oryounger and showed no organic risk factors for dementia were screened for presence of disorientation. Any showing this underwent neuropsychological testing, physical investigations, and structural and functional neuroimaging. Information about day to day cognitive function was also obtained from carers. Results-Eight patients aged 28 to 64 were identified who showed disorientation; in all cases this was accompanied by general intellectual impairment and objective evidence of a dementia syndrome. The patients' schizophrenic symptoms were unexceptional and did not seem sufficient to account for their cognitive impairment. Neuropsychological testing disclosed relative sparing of visual and visuospatial function and language syntax, but pervasive deficits in memory and executive function. Brain CT demonstrated only minor abnormalities but most of the patients showed frontal or temporal hypoperfusion on SPECT. Conclusions-Dementia in schizophrenia seems to be a real entity with a neuropsychological signature similar to that of frontotemporal dementia. Functional but not structural imaging abnormalities may also be characteristic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:07:50