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Titolo:
Glial brain tumor targeting of magnetite nanoparticles in rats
Autore:
Mykhaylyk, O; Cherchenko, A; Ilkin, A; Dudchenko, N; Ruditsa, V; Novoseletz, M; Zozulya, Y;
Indirizzi:
Natl Acad Sci Ukraine, Inst Appl Problems Phys & Biophys, UA-252001 Kiev, Ukraine Natl Acad Sci Ukraine Kiev Ukraine UA-252001 ys, UA-252001 Kiev, Ukraine Acad Med Sci Ukraine, Inst Neurosurg, UA-254050 Kiev, Ukraine Acad Med SciUkraine Kiev Ukraine UA-254050 urg, UA-254050 Kiev, Ukraine First Municipal Hosp, Kiev, Ukraine First Municipal Hosp Kiev UkraineFirst Municipal Hosp, Kiev, Ukraine SII Intermag, Kiev, Ukraine SII Intermag Kiev UkraineSII Intermag, Kiev, Ukraine
Titolo Testata:
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
fascicolo: 1-2, volume: 225, anno: 2001,
pagine: 241 - 247
SICI:
0304-8853(200104)225:1-2<241:GBTTOM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFERRIN RECEPTOR; IRON; PARTICLES; OXIDE; HEME;
Keywords:
contrast agent; ESR; MRI; brain tumor; nanodispersed iron; blood-brain barrier disruption; rat; dextran nanoparticles; glioblastoma; T-2-weighted; tumor imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Mykhaylyk, O Natl Acad Sci Ukraine, Inst Appl Problems Phys & Biophys, POB355, UA-252001 Kiev, Ukraine Natl Acad Sci Ukraine POB 355 Kiev Ukraine UA-252001 Ukraine
Citazione:
O. Mykhaylyk et al., "Glial brain tumor targeting of magnetite nanoparticles in rats", J MAGN MAGN, 225(1-2), 2001, pp. 241-247

Abstract

After intravenous injection into rats, nanodispersed iron preparations accumulated in internal organs but not in the brain. Hyperosmotic blood-brain barrier disruption followed by injection of magnetite-dextran nanoparticlesinto the carotid artery resulted in penetration of particles into the brain tumor and peritumoral tissue of the rats bearing glial brain tumor and T-2-weighted magnetic resonance imaging (MRI) images showed pronounced signalloss in the tumor region. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:12:58