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Titolo:
Circulating levels of interleukin-8 and vascular endothelial growth factorin patients with carotid stenosis
Autore:
Lee, SH; Jeong, MH; Bae, HR; Jeong, SJ; Jang, JY; Lim, YJ; Kim, SH; Kim, JW; Cha, JK;
Indirizzi:
Dong A Univ, Sch Med, Dept Neurol, Pusan 602705, South Korea Dong A Univ Pusan South Korea 602705 t Neurol, Pusan 602705, South Korea Dong A Univ, Sch Med, Inst Med Sci, Pusan 602705, South Korea Dong A UnivPusan South Korea 602705 Med Sci, Pusan 602705, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 2, volume: 16, anno: 2001,
pagine: 198 - 203
SICI:
1011-8934(200104)16:2<198:CLOIAV>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LUNG-CANCER; PERMEABILITY FACTOR; MONONUCLEAR-CELLS; ISCHEMIC STROKE; ATHEROSCLEROSIS; ANGIOGENESIS; NEOVASCULARIZATION; TUMORIGENESIS; PATHOGENESIS; EXPRESSION;
Keywords:
atherosclerosis; endothelial growth factors; interleukin-8; endothelium, vascular; carotid stenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Cha, JK Dong A Univ, Sch Med, Dept Neurol, 1,Dongdaesin Dong 3 Ga, Pusan 602705, South Korea Dong A Univ 1,Dongdaesin Dong 3 Ga Pusan South Korea 602705 Korea
Citazione:
S.H. Lee et al., "Circulating levels of interleukin-8 and vascular endothelial growth factorin patients with carotid stenosis", J KOR MED S, 16(2), 2001, pp. 198-203

Abstract

Interleukin (IL)-8 and vascular endothelial growth factor (VEGF) are important factors that induce the migration and proliferation of endothelial cells, increase the vascular permeability, and the modulate chemotaxis of monocytes. These molecules have been found in human atherosclerotic plaques. However, it is not dear whether the circulating levels of IL-8 and VEGF correlate with the extents of carotid stenosis. In this study, we investigated the relationship between circulating levels of IL-8 as well as VEGF and the extents of carotid stenosis. Sera from 41 patients with carotid stenosis were assessed for concentrations of IL-8 and VEGF by enzyme-linked immunosorbent assay. The degree of stenosis of extracranial carotid artery was calibrated by carotid B-mode ultrasonography. The serum concentration of IL-8 (r=-0.04733, p>0.05) was not correlated with the degree of stenosis. However, the serum concentration of VEGF (r=0.4974, p<0.01) was significantly correlated with the degree of carotid stenosis. These findings suggest that increased serum level of VEGF might be a marker for higher degree of stenosis ofextracranial carotid artery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 11:53:46