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Titolo:
Specific T-cell receptor usage with cytokinemia in Henoch-Schonlein purpura nephritis associated with Staphylococcus aureus infection
Autore:
Hirayama, K; Kobayashi, M; Muro, K; Yoh, K; Yamagata, K; Koyama, A;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Internal Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Tokyo Med Univ, Kasumigaura Hosp, Dept Nephrol, Ibaraki, Osaka, Japan Tokyo Med Univ Ibaraki Osaka Japan , Dept Nephrol, Ibaraki, Osaka, Japan
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 4, volume: 249, anno: 2001,
pagine: 289 - 295
SICI:
0954-6820(200104)249:4<289:STRUWC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXIC SHOCK SYNDROME; IGA NEPHROPATHY; RHEUMATOID-ARTHRITIS; SJOGRENS-SYNDROME; KAWASAKI-DISEASE; IL-2 RECEPTOR; ENTEROTOXIN-B; INTERLEUKIN-2; SUPERANTIGEN; REPERTOIRE;
Keywords:
cytokine; Henoch-Schonlein purpura nephritis; Staphylococcus aureus; T-cell receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Hirayama, K Univ Tsukuba, Inst Clin Med, Dept Internal Med, 1-1-1 Ten-nodai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Ten-nodai Tsukuba Ibaraki Japan 3058575 pan
Citazione:
K. Hirayama et al., "Specific T-cell receptor usage with cytokinemia in Henoch-Schonlein purpura nephritis associated with Staphylococcus aureus infection", J INTERN M, 249(4), 2001, pp. 289-295

Abstract

Objectives, We sought to evaluate the mechanism of Henoch-Schonlein purpura nephritis (HSPN) associated with Staphylococcus aureus (S. aureus) infection. Design, We evaluated six male patients with HSPN associated with S. aureusinfection. Routine laboratory examinations, bacteriological examination, histological examination, and analysis of serum levels were performed in allcases. In peripheral blood mononuclear cells obtained from the six patients and 45 normal individuals were stained with labelled-monoclonal antibodies against six variable parts of the beta -chain (V beta) of the T-cell receptor (TCR), and stained cells were analysed by flow cytometry. Results, Patients with HSPN associated with S. aureus infection showed features of the nephrotic syndrome with rapidly progressive glomerulonephritis. as well as varying degrees of mesangial proliferative glomerulonephritis with crescent formation, Serological examination showed elevated levels of serum IgA and IgG as well as immune complexes after the onset of infection. The percentage of V beta-(5.2 + 5.3) and V beta 8-positive cells in patients with HSPN were significantly higher than in normal individuals; moreover, specific TCR-V beta usage was not observed in patients with HSPN whose S.aureus infection had improved. Serum levels of IL-1 beta, IL-2, IL-6, IL-8and TNF-alpha in patients with HSPN were significantly higher than in normal individuals, and normalized at the healing stage of S. aureus infection. Conclusion, Conventional antigens and/or staphylococcal enterotoxins originated from S. aureus might have been involved in the pathogenesis of HSPN in the present cohort. Therefore, steroid or other immunosuppressive therapies could not be utilized despite the high activity of glomerulonephritis, and as a result the prognoses of these cases of HSPN were serious.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:36:03