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Titolo:
IFN-gamma affects both the stability and the intracellular transport of class I MHC complexes
Autore:
Fromm, SV; Ehrlich, R;
Indirizzi:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 mmunol, IL-69978 Tel Aviv, Israel
Titolo Testata:
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
fascicolo: 4, volume: 21, anno: 2001,
pagine: 199 - 208
SICI:
1079-9907(200104)21:4<199:IABTSA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; HIGHLY ONCOGENIC ADENOVIRUS-12; DEPENDENT REDUCTASE ERP57; HLA CLASS-I; INTERFERON-GAMMA; MONOCLONAL-ANTIBODIES; PEPTIDE-TRANSPORT; CELL BIOLOGY; MOLECULES; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Ehrlich, R Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, UnitedKingdom Bldg,Room 321, IL-69978 Tel Aviv, Israel Tel Aviv Univ United Kingdom Bldg,Room 321 Tel Aviv Israel IL-69978
Citazione:
S.V. Fromm e R. Ehrlich, "IFN-gamma affects both the stability and the intracellular transport of class I MHC complexes", J INTERF CY, 21(4), 2001, pp. 199-208

Abstract

In accordance with the key role of major histocompatibility complex (MHC) class I molecules in the adaptive immune response against viruses, their expression can be enhanced by the potent cytokine interferon-gamma (IFN-gamma), which upregulates the expression of multiple components in the pathway of class I-restricted antigen presentation. In this study, we analyzed the effect of IFN-gamma treatment on class I formation, peptide editing, trafficking, and cell surface expression. We show that IFN-gamma treatment promotes significantly the assembly and cell surface expression of stable class I complexes. Yet the existence of large intracellular pools of both free class I heavy chains and suboptimal class I complexes indicates that the optimal peptide supply limits cell surface expression levels of class I complexes. Unexpectedly, we found that IFN-gamma appears generally to slow the maturation rates of both class I complexes and transferrin receptors, Apparently, IFN-gamma causes prolonged retention of molecules in the endoplasmic reticulum (ER) because it regulates the expression of ER-residing proteins thatparticipate in protein maturation. Consequently, it induces more rigorous ER quality control. The significance of these effects of IFN-gamma for in vivo immune responses is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:26:38