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Titolo:
Clones of Streptococcus pneumoniae isolated from nasopharyngeal carriage and invasive disease in young children in central Tennessee
Autore:
Robinson, DA; Edwards, KM; Waites, KB; Briles, DE; Crain, MJ; Hollingshead, SK;
Indirizzi:
Univ Alabama, Dept Med, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 , Dept Med, Birmingham, AL 35294 USA Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ept Pathol, Birmingham, AL 35294 USA Univ Alabama, Dept Pediat, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ept Pediat, Birmingham, AL 35294 USA Univ Alabama, Dept Comparat Med, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 mparat Med, Birmingham, AL 35294 USA Vanderbilt Univ, Dept Pediat, Div Infect Dis, Nashville, TN USA VanderbiltUniv Nashville TN USA diat, Div Infect Dis, Nashville, TN USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 10, volume: 183, anno: 2001,
pagine: 1501 - 1507
SICI:
0022-1899(20010515)183:10<1501:COSPIF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
OTITIS-MEDIA; IDENTIFICATION; COLONIZATION; SEROTYPES; SEQUENCE; ACQUISITION; CONFIDENCE; RESISTANCE; TREES; LIFE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hollingshead, SK Univ Alabama, Dept Med, 654 BBRB,845 19th St S, Birmingham, AL 35294 USA Univ Alabama 654 BBRB,845 19th St S Birmingham AL USA 35294
Citazione:
D.A. Robinson et al., "Clones of Streptococcus pneumoniae isolated from nasopharyngeal carriage and invasive disease in young children in central Tennessee", J INFEC DIS, 183(10), 2001, pp. 1501-1507

Abstract

To determine whether nasopharyngeal carriage isolates of Streptococcus pneumoniae are of the same genetic background as isolates that caused invasivedisease in one community, IS1167 and boxA genotypes were obtained for 182 pneumococcal isolates from children living in central Tennessee. The isolates represented 70 combined IS1167-boxA genotypes. The genotypic diversity of the invasive isolates was significantly less than that of the total population (P=.003). Most of the carriage isolates belonged to genotypes unique to carriage, whereas most of the invasive isolates belonged to genotypes common to carriage and disease (P = .02). Monte Carlo simulations showed a greater number of genotypes unique to carriage than can be explained by chance (P<.05 in all cases). Two genotypes were identified by multilocus sequence typing as members of globally disseminated clones, and one such genotype that was strictly carriage in this sample caused disease in other studies. Thus, clones can have different propensities for carriage and invasion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:21:22