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Titolo:
Effect of partial and sham hepatectomy on the growth of a hepatocellular carcinoma
Autore:
Barbeito, CG; Garcia, MN; Flamini, MA; Andrini, LB; Badran, AF;
Indirizzi:
Natl Univ La Plata, Fac Ciencias Med, Catedra Histol & Embriol A, RA-1900 La Plata, Argentina Natl Univ La Plata La Plata Argentina RA-1900 A-1900 La Plata, Argentina
Titolo Testata:
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
fascicolo: 1, volume: 20, anno: 2001,
pagine: 153 - 158
SICI:
0392-9078(200103)20:1<153:EOPASH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-REGENERATION; TUMOR-GROWTH; FACTOR-ALPHA; RATS; BETA; HEPATOCARCINOGENESIS; PROLIFERATION; INHIBITION; MECHANISM; CANCER;
Keywords:
cell proliferation; hepatocellular carcinoma; liver regeneration; surgical stress; colchicine-arrested metaphases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Barbeito, CG Natl Univ La Plata, Fac Ciencias Med, Catedra Histol & Embriol A, 60 & 118, RA-1900 La Plata, Argentina Natl Univ La Plata 60 & 118 La Plata Argentina RA-1900 ntina
Citazione:
C.G. Barbeito et al., "Effect of partial and sham hepatectomy on the growth of a hepatocellular carcinoma", J EXP CL C, 20(1), 2001, pp. 153-158

Abstract

We examined the effect of pal-tial hepatectomy on the proliferation of hepatoma ES 12a grafted into C3H/S mice compared to tumor growth in sham-hepatectomized controls. The animals were sacrificed every 4 hrs during three days fi om the 6(th) to the 78(th) h following each type of surgery. Unoperated tumor-bearing mice were likewise killed as controls, but only during onecomplete circadian period. All animals received 2 mug of colchicine per g of body weight intraperitoneally 4 hrs before decapitation. Measurement of mitotic indices in hematoxylin-eosin-stained tumor samples revealed a decrease in proliferation and a modification of the diurnal mitotic-activity profile in the hepatectomized and sham-operated animals from the first day after surgery. These differences persisted by the third postoperative day onlyin the hepatectomized animals. Thus, although surgical stress may initially affect tumor growth, the latter results must be the effect of the influence of the hepatic regeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:24:39