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Titolo:
Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis
Autore:
Tsuji, S; Tsujii, M; Kawano, S; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med A8, Dept Internal Med & Therapeut, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 erapeut, Suita, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
fascicolo: 1, volume: 20, anno: 2001,
pagine: 117 - 129
SICI:
0392-9078(200103)20:1<117:CUAAPC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE-2; HELICOBACTER-PYLORI INFECTION; APC(DELTA-716) KNOCKOUT MICE; MESSENGER-RNA EXPRESSION; ACTIVATED RECEPTOR-GAMMA; HUMAN GASTRIC-CARCINOMA; 3' UNTRANSLATED REGION; NITRIC-OXIDE SYNTHASE; COLON-CANCER CELLS;
Keywords:
angiogenesis; tumor immunology; VEGF; bFGF; TGF-beta; cyclooxygenase; prostaglandin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuji, S Osaka Univ, Grad Sch Med A8, Dept Internal Med & Therapeut, 2-2 Yamadaoka,Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
S. Tsuji et al., "Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis", J EXP CL C, 20(1), 2001, pp. 117-129

Abstract

The present paper reviews current concepts on the role of cyclooxygenase (COX) in the development of malignant tumors. An inducible isoform of cyclooxygenase is expressed in neoplastic, pre-neoplastic, and peri-neoplastic cells by mutation of oncogenes (such as ms), tumor promoters, mitogens, cytokines, their receptors, and pathogenic factors such as Helicobacter. Cells overexpressing cox-2 escape apoptosis, have abnormal cell-to-cell interactions, and acquire invasive phenotypes. On the other hand, angiogenesis plays a key role in the development of malignant tumors. Both in vitro and in vivo studies indicate that cox-2 overexpression upregulates angiogenic factorsin neoplastic cells and promotes tumor angiogenesis. It is also possible that cox-2 expression upregulates angiogenic factors in peri-neoplastic cells that express the isozyme. Interestingly, cox-1, the other isozyme that isexpressed in tumor vascular endothelia, participates in tumor angiogenesis, because an anti-sense oligonucleotide of cox-1 suppresses in vitro angiogenesis induced by cox-2-overexpressing cells. A non-specific COX inhibitor,not a specific COX-2 inhibitor, reduced growth and angiogenesis in cancer xenografts by inhibition of COX-1 in vascular endothelial cells, even when the tumor did not express COX-2. These results demonstrate that COX inhibitors suppress angiogenesis and tumor growth by inhibiting expression of angiogenic factors and vascular endothelial cell migration. Furthermore, another concept is emerging to indicate that prostaglandins (COX-2 products and mediators of classic inflammation) suppress host immunity against tumors. This evidence supports the hypothesis that COX is an important perigenetic factor in the development of cancer growth, and offers a new strategy againstcancer using COX inhibitors (nonsteroidal anti-inflammatory drugs).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:44:15