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Titolo:
Chemopreventive effect of Ginkgo biloba extract against benzo(a)pyrene-induced forestomach carcinogenesis in mice: Amelioration of doxorubicin cardiotoxicity
Autore:
Agha, AM; El-Fattah, AAA; Al-Zuhair, HH; Al-Rikabi, AC;
Indirizzi:
King Saud Univ, Coll Pharm, Dept Pharmacol, Riyadh 11495, Saudi Arabia King Saud Univ Riyadh Saudi Arabia 11495 col, Riyadh 11495, Saudi Arabia
Titolo Testata:
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
fascicolo: 1, volume: 20, anno: 2001,
pagine: 39 - 50
SICI:
0392-9078(200103)20:1<39:CEOGBE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE PRODUCTION; CELLS; EGB-761; CANCER; ACID; DNA; ENHANCEMENT; REPERFUSION; INHIBITORS;
Keywords:
Ginkgo biloba; doxorubicin; benzo(a)pyrene; forestomach cancer; glutathione; glutathione S-transferase; cytochrome P-450 reductase; nitric oxide; glucose-6-phosphate dehydrogenase; tumor necrosis factor alpha; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Al-Zuhair, HH King Saud Univ, Coll Pharm, Dept Pharmacol, POB 22452, Riyadh 11495, SaudiArabia King Saud Univ POB 22452 Riyadh Saudi Arabia 11495 diArabia
Citazione:
A.M. Agha et al., "Chemopreventive effect of Ginkgo biloba extract against benzo(a)pyrene-induced forestomach carcinogenesis in mice: Amelioration of doxorubicin cardiotoxicity", J EXP CL C, 20(1), 2001, pp. 39-50

Abstract

Ginkgo biloba extract (EGb) is a natural product that possesses antioxidant and anticlastogenic properties. The current study was conducted to investigate the effect of EGb on benzo(a)pyrene (BP)-induced forestomach neoplasia, and to explore its possible beneficial effects against doxorubicin (Dox)-induced cardiotoxicity. Tumor was induced in female Swiss albino mice by oral administration of 1 mg BP, twice weekly for four weeks. EGb was given, at a daily oral dose of 150 mg kg(-1), two weeks before and during BP administration. Dox was given ip at a dose of 1.5 mg kg(-1), once weekly, for four weeks, during BP administration. EGb and Dox were given as combined or monotherapies. Results of the present investigation revealed that EGb blunted forestomach tumor multiplicity, as compared to control tumor bearing group. It also exhibited high activity to induce cytosolic glutathione S-transferase and glucose-6-phosphate dehydrogenase (G6PDH) in liver, as well as replenished hepatic glutathione that have been inhibited or depleted by tumorigenesis. Furthermore, it normalized nitric oxide (NO) serum level, withoutany observed alteration in neither the activity of liver microsomal NADPH-cytochrome P-450 reductase nor serum level of tumor necrosis factor-alpha (TNF alpha). Similar results have been obtained with Dox, but it failed to affect GGPDH activity, while increased semm TNF alpha and NO levels. The combined therapy did not add further to the anticarcinogenic effect of Dox, however it succeeded in ameliorating the deleterious effects of Dox on the heart; as evidenced by the reduction of cardiac lipoperoxidation, with modulation of Dox-induced pathological changes. Therefore, EGb confers a beneficial chemopreventive effect against BP-induced gastric carcinogenesis in mice, and possesses a salutary ameliorating potential on the cardiotoxic effects of Dox.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:14:56