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Titolo:
Effects of paeoniflorin on the formalin-induced nociceptive behaviour in mice
Autore:
Tsai, HY; Lin, YT; Tsai, CH; Chen, YF;
Indirizzi:
China Med Coll, Dept Pharmacol, Taichung 404, Taiwan China Med Coll Taichung Taiwan 404 Dept Pharmacol, Taichung 404, Taiwan China Med Coll Hosp, Dept Pharm, Taichung 404, Taiwan China Med Coll HospTaichung Taiwan 404 Dept Pharm, Taichung 404, Taiwan China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan China Med Coll Hosp Taichung Taiwan 404 pt Med Res, Taichung 404, Taiwan
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 2-3, volume: 75, anno: 2001,
pagine: 267 - 271
SICI:
0378-8741(200105)75:2-3<267:EOPOTF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC GMP PATHWAY; NITRIC-OXIDE; L-ARGININE; ANALGESIA; HYPERALGESIA; INVOLVEMENT; ACTIVATION; MORPHINE; BRAIN; RAT;
Keywords:
paeoniflorin; formalin; nociceptive behavior; antinociception;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, YF China Med Coll, Dept Pharmacol, No 91 Hsueh Shih Rd, Taichung 404, Taiwan China Med Coll No 91 Hsueh Shih Rd Taichung Taiwan 404 4, Taiwan
Citazione:
H.Y. Tsai et al., "Effects of paeoniflorin on the formalin-induced nociceptive behaviour in mice", J ETHNOPHAR, 75(2-3), 2001, pp. 267-271

Abstract

In this study, we attempted to identify the mechanisms of paeoniflorin on antinociceptive effects in mice. Paeoniflorin (48, 96, 240, 480 mug, i.c.v.) showed dose-related antinociception both on the early and late phases of formalin test in mice. Moreover, paeoniflorin (48 mug, i.c.v.) could potentiate the antinociception of morphrine (0.5, 1.0 mg/kg, s.c.) in the formalin test. However, the antinociceptive effects of paeoniflorin were not potentiated by L-arginine (600 mg/kg, i.p.) or antagonized by beta -funaltrexamine (beta -FNA) (10 mug, i.c.v.), ICI-174,864 (1 mug, i.c.v.) and ryanodine (10 ng, i.c.v.) on both the early and late phases of formalin test. L-NAME (75 mg/kg, i.p.) could reverse the effect of paeoniflorin on the late phaseof formalin test. Naloxone (1 mg/kg, i.p.) and nor-binaltorphimine (nor-BNI) (1 mug, i.c.v.) could block the paeoniflorin-induced antinociception on the early phase of formalin test. These results suggested that the central antinociceptive effects of paeoniflorin on formalin test in mice were mediated by the activation of kappa -opioid receptor and not related to the increase of intracellular calcium. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:05:12