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Titolo:
Screening of several Indonesian medicinal plants for their inhibitory effect on histamine release from RBL-2H3 cells
Autore:
Ikawati, Z; Wahyuono, S; Maeyama, K;
Indirizzi:
Ehime Univ, Sch Med, Dept Pharmacol, Shigenobu, Ehime 7910295, Japan EhimeUniv Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Gadjah Mada Univ, Fac Pharm, Yogyakarta, Indonesia Gadjah Mada Univ Yogyakarta Indonesia Fac Pharm, Yogyakarta, Indonesia
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 2-3, volume: 75, anno: 2001,
pagine: 249 - 256
SICI:
0378-8741(200105)75:2-3<249:SOSIMP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
2H3 CELLS; CURCUMA-XANTHORRHIZA; MECHANISM; SIGNAL; ASTHMA; THAPSIGARGIN; EXOCYTOSIS; FLAVONOIDS; RECEPTOR; KINASES;
Keywords:
histamine; Indonesian medicinal plants; jamu; RBL-2H3 cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Maeyama, K Ehime Univ, Sch Med, Dept Pharmacol, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Ehime 7910295, Japan
Citazione:
Z. Ikawati et al., "Screening of several Indonesian medicinal plants for their inhibitory effect on histamine release from RBL-2H3 cells", J ETHNOPHAR, 75(2-3), 2001, pp. 249-256

Abstract

Twelve alcoholic extracts and 12 hexane extracts of plant materials selected on the basis of medicinal folklore for asthma treatment in Indonesia were studied for their activity in inhibiting histamine release from RBL-2H3 cells (rat basophilic leukemia cell line), a tumor analog of mast cells. Theresults of screening indicated that five alcoholic extracts (Plantago major leaves, Eucalyptus globulus leaves and fruit, Cinnamomum massoiae cortex,Vitex trifolia leaves) and two hexane extracts (Eucalyptus globulus leaves, Vitex trifolia leaves) inhibited IgE-dependent histamine release from RBL-2H3 cells. The inhibitory effects were found to be more than 80% for extract concentrations of 0.5 mg/ml. The results indicate that the extracts contain active compounds that inhibit mast-cell degranulation, and provide insight into the development of new drugs for treating asthma and/or allergic disease. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:43:03