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Titolo:
Evaluation of the protective potential of Ambrosia maritima extract on acetaminophen-induced liver damage
Autore:
Ahmed, MB; Khater, MR;
Indirizzi:
Fac Sci, Dept Chem, Beni Suef, Egypt Fac Sci Beni Suef EgyptFac Sci, Dept Chem, Beni Suef, Egypt Inst Hort Res, Med & Aromat Plant Res Dept, Cairo, Egypt Inst Hort Res Cairo Egypt es, Med & Aromat Plant Res Dept, Cairo, Egypt
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 2-3, volume: 75, anno: 2001,
pagine: 169 - 174
SICI:
0378-8741(200105)75:2-3<169:EOTPPO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOPROTECTIVE ACTIVITY; INDUCED HEPATOTOXICITY; HEPATIC NECROSIS; GLUTATHIONE; PARACETAMOL; INHIBITION; OXIDASE; PLANT; METABOLITES; INDUCTION;
Keywords:
Ambrosia maritima; acetaminophen; hepatotoxicity; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Ahmed, MB Fac Sci, Dept Chem, Beni Suef, Egypt Fac Sci Beni Suef EgyptFac Sci, Dept Chem, Beni Suef, Egypt
Citazione:
M.B. Ahmed e M.R. Khater, "Evaluation of the protective potential of Ambrosia maritima extract on acetaminophen-induced liver damage", J ETHNOPHAR, 75(2-3), 2001, pp. 169-174

Abstract

The hepatoprotective activity of the aqueous-methanolic extract of Ambrosia maritima was investigated against acetaminophen (paracetamol, 4-hydroxy acetanilide) induced hepatic damage. Acetaminophen at the dose of 640 mg/kg produced liver damage in rats as manifested by the significant (P < 0.001) rise in serum levels of glutamate oxaloacetate transaminase (AST), glutamate pyruvate transaminase (ALT) and alkaline phosphatase (ALP) to 1178.5 +/- 118.05; 607.5 +/- 32.6 and 274.16 +/- 8.89 IU/I (n = 10), respectively, compared with respective control values of 97.83 +/- 3.23; 46.0 +/- 3.92 and 168.67 +/- 7.86 IU/l. Pretreatment of rats with the plant extract (100 and 200 mg/kg) lowered significantly (P < 0.001) the respective serum AST to 203.3 +/- 5.74 and 157.1 +/- 8.78 IU/l, ALT to 138.67 +/- 7.7 and 87.5 +/- 3.6IU/l and ALP levels to 238.0 +/- 5.89 and 206.5 +/- 7.5 IU/l, respectively. Treatment of rats with acetaminophen led to a marked increase in lipid peroxidation as measured by malondialdehyde (MDA) (42%). This was associated with a significant reduction of the hepatic antioxidant system e.g. reducedglutathione (GSH) (65%); glutathione reductase (GSH-R) (35%), total glutathione peroxidase (GSH-Px) (32%) and glutathione-S-transferase (GST) (16%). These biochemical alterations resulting from acetaminophen administration were inhibited by pretreatment with A. maritima L. extract. These data suggest that the plant A. maritima L. may act as a hepatoprotective and antioxidant agent. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:24:01