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Titolo:
Dynamics of viral load in plasma and HIV DNA in lymphocytes during highly active antiretroviral therapy (HAART): High viral burden in macrophages after 1 year of treatment
Autore:
Garbuglia, AR; Zaccarelli, M; Calcaterra, S; Cappiello, G; Marini, R; Benedetto, A;
Indirizzi:
IRCCS, Spallanzani Hosp, Ctr Virol, I-00149 Rome, Italy IRCCS Rome ItalyI-00149 pallanzani Hosp, Ctr Virol, I-00149 Rome, Italy
Titolo Testata:
JOURNAL OF CHEMOTHERAPY
fascicolo: 2, volume: 13, anno: 2001,
pagine: 188 - 194
SICI:
1120-009X(200104)13:2<188:DOVLIP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; BLOOD MONOCYTES; COMBINATION THERAPY; MONONUCLEAR-CELLS; PROVIRAL DNA; INFECTION; QUANTIFICATION; INDIVIDUALS; RESERVOIR; DECAY;
Keywords:
HAART; HIV-1; CD4+T cells; monocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Garbuglia, AR IRCCS, L Spallanzani Inst, Ctr Virol, Via Portuense 292, I-00149 Rome, Italy IRCCS Via Portuense 292 Rome Italy I-00149 0149 Rome, Italy
Citazione:
A.R. Garbuglia et al., "Dynamics of viral load in plasma and HIV DNA in lymphocytes during highly active antiretroviral therapy (HAART): High viral burden in macrophages after 1 year of treatment", J CHEMOTHER, 13(2), 2001, pp. 188-194

Abstract

In this study we evaluated the level of HIV RNA in plasma and HIV DNA in peripheral blood cells. Sixteen antiretroviral-experienced HIV patients withsevere immune suppression were included in the study. After the first month, 56.2% of the patients showed undetectable levels of HIV RNA, this percentage remaining stable after 1 year (53.3%). At enrollment, 7 patients (43.7%) with a low CD4+T cell count (mean 22 per mm(3) versus 73) showed HIV DNAlevels below the limit of detection (5 copies/10(5)) in lymphocytes. They all subsequently had increased HIV DNA that became detectable between the first and the third month of therapy, associated with an increase of the CD4T cell count (mean 22 to 95 / mm(3)); in 4 of these patients this increasewas transitory, becoming undetectable again after one year. In 7 out of the 8 patients with detectable HIV DNA at enrollment, the HIV DNA level decreased over time, Seven out of 15 patients at 1 year (46.7%) showed both undetectable levels of HIV RNA in plasma and HIV DNA in lymphocytes (p<0.05); these patients had a higher CD4+T cell count at baseline (mean 75 versus 25 / mm(3)) and a higher increase (306 versus 177 / mm3) after 1 year, PCR-based dilution assay carried out at 1 year showed that all patients had a consistent amount of HIV DNA positive- CD4+T lymphocytes and macrophages, with higher values in these last cells. The data indicate that a durable reservoir of virus is still present in both lymphocytes and monocytes, even after long-lasting HAART treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:19:11