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Titolo:
OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta 1 integrin and regulates proliferation and migration of oligodendrocytes
Autore:
Tiwari-Woodruff, SK; Buznikov, AG; Vu, TQ; Micevych, PE; Chen, K; Kornblum, HI; Bronstein, JM;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Neurobiol, Los Angeles, CA 90024 USAUniv Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol & Pediat, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Inst Brain Res, Los Angeles, CA 90024 USAUniv Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
JOURNAL OF CELL BIOLOGY
fascicolo: 2, volume: 153, anno: 2001,
pagine: 295 - 305
SICI:
0021-9525(20010416)153:2<295:OFACWA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLARIZED EPITHELIAL-CELLS; TUMOR-SUPPRESSOR PROTEIN; TIGHT JUNCTION STRANDS; EMBRYONIC STEM-CELLS; TRANSMEMBRANE-4 SUPERFAMILY; IMMUNOGLOBULIN SUPERFAMILY; MYELIN PROTEINS; TM4SF PROTEINS; CNS MYELIN; ZO-1;
Keywords:
tight junctions; myelin; TM4SF; brain; OAP-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Bronstein, JM Univ Calif Los Angeles, Sch Med, Dept Neurol, RNRC 710 Westwood Plaza, LosAngeles, CA 90024 USA Univ Calif Los Angeles RNRC 710 Westwood Plaza Los Angeles CA USA 90024
Citazione:
S.K. Tiwari-Woodruff et al., "OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta 1 integrin and regulates proliferation and migration of oligodendrocytes", J CELL BIOL, 153(2), 2001, pp. 295-305

Abstract

Oligodendrocyte-specific protein (OSP)/claudin-11 is a major component of central nervous system myelin and forms tight junctions (TJs) within myelinsheaths. TJs are essential for forming a paracellular barrier and have been implicated in the regulation of growth and differentiation via signal transduction pathways. We have identified an OSP/claudin-11-associated protein(OAP)1, using a yeast two-hybrid screen. OAP-1 is a novel member of the tetraspanin superfamily, and it is widely expressed in several cell types, including oligodendrocytes, OAP-1, OSP/claudin-11, and beta1 integrin form a complex as indicated by coimmunoprecipitation and confocal immunocytochemistry. Overexpression of OSP/claudin-11 or OAP-1 induced proliferation in an oligodendrocyte cell line. Anti-OAP-1, anti-OSP/claudin-11, and anti-beta1 integrin antibodies inhibited migration of primary oligodendrocytes, and migration was impaired in OSP/claudin-11-deficient primary oligodendrocytes. These data suggest a role for OSP/claudin-11, OAP-1, and beta1 integrin complex in regulating proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:54:40