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Titolo:
Desmoglein isoform distribution affects stratum corneum structure and function
Autore:
Elias, PM; Matsuyoshi, N; Wu, H; Lin, CY; Wang, ZH; Brown, BE; Stanley, JR;
Indirizzi:
Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dermatol, Philadelphia, PA 19104 USA Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF CELL BIOLOGY
fascicolo: 2, volume: 153, anno: 2001,
pagine: 243 - 249
SICI:
0021-9525(20010416)153:2<243:DIDASC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEMPHIGUS-VULGARIS ANTIGEN; HUMAN INVOLUCRIN PROMOTER; DESMOSOMAL ADHESION; EPIDERMIS; FOLIACEUS; MICE; GENE; SKIN; LOCALIZATION; PERMEABILITY;
Keywords:
cadherins; cell adhesion molecules; desmosome; epidermis; skin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Stanley, JR Univ Penn, Dept Dermatol, 211 CRB,415 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn 211 CRB,415 Curie Blvd Philadelphia PA USA 19104 USA
Citazione:
P.M. Elias et al., "Desmoglein isoform distribution affects stratum corneum structure and function", J CELL BIOL, 153(2), 2001, pp. 243-249

Abstract

Desmogleins are desmosomal cadherins that mediate cell-cell adhesion. In stratified squamous epithelia there are two major isoforms of desmoglein, 1 and 3, with different distributions in epidermis and mucous membrane. Sinceeither desmoglein isoform alone can mediate adhesion, the reason for theirdifferential distribution is not known. To address this issue, we engineered transgenic mice with desmoglein 3 under the control of the involucrin promoter. These mice expressed desmoglein 3 with the same distribution in epidermis as found in normal oral mucous membranes, while expression of other major differentiation molecules was unchanged. Although the nucleated epidermis appeared normal, the epidermal stratum corneum was abnormal with grossscaling, and a lamellar histology resembling that of normal mucous membrane. The mice died shortly after birth with severe dehydration, suggesting excessive transepidermal water loss, which was confirmed by in vitro and in vivo measurement. Ultrastructure of the stratum corneum showed premature loss of cohesion of corneocytes. This dysadhesion of corneocytes and its contribution to increased transepidermal water loss was confirmed by tape stripping. These data demonstrate that differential expression of desmoglein isoforms affects the major function of epidermis, the permeability barrier, by altering the structure of the stratum corneum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:06:03