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Titolo:
Binding of bis-linked netropsin derivatives in the parallel-stranded hairpin form to DNA
Autore:
Surovaya, AN; Burckhardt, G; Grokhovsky, SL; Birch-Hirschfeld, E; Nikitin, AM; Fritzsche, H; Zimmer, C; Gursky, GV;
Indirizzi:
Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 117984, Russia Russian Acad Sci Moscow Russia 117984 l Biol Inst, Moscow 117984, Russia Univ Jena, Inst Mol Biol, D-6900 Jena, Germany Univ Jena Jena Germany D-6900 Jena, Inst Mol Biol, D-6900 Jena, Germany Univ Jena, Inst Virol, D-6900 Jena, Germany Univ Jena Jena Germany D-6900 niv Jena, Inst Virol, D-6900 Jena, Germany Univ Oslo, Ctr Med Studies, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Ctr Med Studies, Oslo, Norway
Titolo Testata:
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
fascicolo: 5, volume: 18, anno: 2001,
pagine: 689 - 701
SICI:
0739-1102(200104)18:5<689:BOBNDI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINOR-GROOVE-BINDING; SEQUENCE-SPECIFIC RECOGNITION; DOUBLE-HELICAL DNA; DISTAMYCIN-A; BASE-PAIRS; DODECAMER D(CGCAAATTTGCG); CRYSTAL-STRUCTURE; PEPTIDE MOTIF; LIGANDS; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Zimmer, C Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 117984, Russia Russian Acad Sci Moscow Russia 117984 t, Moscow 117984, Russia
Citazione:
A.N. Surovaya et al., "Binding of bis-linked netropsin derivatives in the parallel-stranded hairpin form to DNA", J BIO STRUC, 18(5), 2001, pp. 689-701

Abstract

Cis-diammine Pt(II)- bridged bis-netropsin and oligomethylene-bridged bis-netropsin in which two monomers are linked in a tail-to-tail manner bind tothe DNA oligomer with the sequence 5'-CCTATATCC-3' in a parallel-stranded hairpin form with a stoichiometry 1:I. The difference circular dichroism (CD) spectra characteristic of binding of these ligands in the hairpin form are similar. They differ from CD patterns obtained for binding to the same duplex of another bis-netropsin in which two netropsin moieties were linked in a head-to-tail manner. This reflects the fact that tail-to-tail and head-to-tail bis-netropsins use parallel and antiparallel side-by-side motifs, respectively, for binding to DNA in the hairpin forms. The binding affinityof cis-diammine Pt(II)- bridged bis-netropsin in the hairpin form to DNA oligomers with nucleotide sequences 5'-CCTATATCC-3' (I), 5'-CCTTAATCC-3' (II), 5'-CCTTATTCC-3' (III), 5'-CCTTTTTCC-3' (IV) and 5'-CCAATTTCC-3' (V) decreases in the order I = II > III > IV > V. The binding of oligomethylene-bridged bis-netropsin in the hairpin form follows a similar hierarchy. An opposite order of sequence preferences is observed for partially bonded monodentate binding mode of the synthetic ligand.

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Documento generato il 26/09/20 alle ore 12:10:38