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Titolo:
Correlation of thoracic and lumbar vertebral failure loads with in situ vs. ex situ dual energy X-ray absorptiometry
Autore:
Burklein, D; Lochmuller, EM; Kuhn, V; Grimm, J; Barkmann, R; Muller, R; Eckstein, F;
Indirizzi:
Univ Munich, Inst Anat, Musculoskeletal Res Grp, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 etal Res Grp, D-80336 Munich, Germany Univ Munich, Frauenklin, D-80337 Munich, Germany Univ Munich Munich Germany D-80337 , Frauenklin, D-80337 Munich, Germany Radiol Diagnost Klin, Kiel, Germany Radiol Diagnost Klin Kiel GermanyRadiol Diagnost Klin, Kiel, Germany Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Beth Israel Deaconess Med Ctr, Orthopaed Biomech Lab, Boston, MA 02215 USABeth Israel Deaconess Med Ctr Boston MA USA 02215 b, Boston, MA 02215 USA
Titolo Testata:
JOURNAL OF BIOMECHANICS
fascicolo: 5, volume: 34, anno: 2001,
pagine: 579 - 587
SICI:
0021-9290(200105)34:5<579:COTALV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; QUANTITATIVE COMPUTED-TOMOGRAPHY; BODY COMPRESSIVE STRENGTH; PHOTON-ABSORPTIOMETRY; IN-VITRO; CALCANEAL ULTRASOUND; PREDICTION; SPINE; DENSITOMETRY; FRACTURES;
Keywords:
vertebral failure; spine; DXA; bone strength; biomechanical testing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Eckstein, F Univ Munich, Inst Anat, Musculoskeletal Res Grp, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 , D-80336 Munich, Germany
Citazione:
D. Burklein et al., "Correlation of thoracic and lumbar vertebral failure loads with in situ vs. ex situ dual energy X-ray absorptiometry", J BIOMECHAN, 34(5), 2001, pp. 579-587

Abstract

In this study we explore the hypothesis that estimates of failure loads inthe thoracic spins by lumbar dual energy X-ray absorptiometry (DXA) are compromised of skeletal heterogeneity throughout the spine and artifacts of spinal DXA. We studied the correlation between mechanical failure loads of thoracic and lumbar vertebrae, and that of in situ vs, ex situ lumbar DXA with thoracic and lumbar fracture loads, respectively. One hundred and nineteen subjects (76 female, age 82 +/- 9 yr; 43 male, age 77 +/- 11 yr) were examined under in situ conditions (anterior-posterior direction), the scans being repeated ex situ (lateral projection) in 68 cases. The failure loads of thoracic vertebrae (T) 6 and 10, and lumbar vertebra (L) 3 were determined in axial compression, using a functional 3-segment unit. The correlation between thoracic failure loads (T6 vs. T10) was significantly (p < 0.01) higher (r = 0.85) than those between thoracic and lumbar vertebrae (r = 0.68 and 0.61, respectively). Lateral ex situ DXA displayed a significantly higher correlation (p < 0.05) with lumbar vertebral fracture loads than in situanterior-posterior DXA (r = 0.85 vs. 0.71), but the correlation of thoracic failure loads with lateral ex situ lumbar DXA was similar to that obtained in situ in anterior-posterior direction (r = 0.69 vs, 0.69 for T10, and r= 0.61 vs. 0.65 for T6). The correlation between fracture loads of different spinal segments, and between DXA and failure loads was not significantlydifferent between men and women. The results demonstrate a substantial heterogeneity of mechanical competence throughout the spine in elderly individuals. Because of the high incidence of fractures in the thoracic spine, these findings suggest that, clinically, lateral DXA involves no relevant advantage over anterior-posterior measurements of the lumbar spine. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 29/11/20 alle ore 15:44:26