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Titolo:
The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis
Autore:
Seger, R; Hanoch, T; Rosenberg, R; Dantes, A; Merz, WE; Strauss, JF; Amsterdam, A;
Indirizzi:
Weizmann Inst Sci, Dept Regulat Biol, IL-71600 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-71600 Biol, IL-71600 Rehovot, Israel Weizmann Inst Sci, Dept Mol Cell Biol, IL-71600 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-71600 Biol, IL-71600 Rehovot, Israel Univ Heidelberg, Biochem Zentrum Heidelberg, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Univ Penn, Ctr Res Reprod Womens Hlth, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 mens Hlth, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 17, volume: 276, anno: 2001,
pagine: 13957 - 13964
SICI:
0021-9258(20010427)276:17<13957:TESCIG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE REGULATORY PROTEIN; IMMORTALIZED GRANULOSA-CELLS; ARTERIAL SMOOTH-MUSCLE; LEYDIG TUMOR-CELLS; GROWTH-FACTOR; COUPLED RECEPTORS; STAR GENE; KINASE-A; ACTIVATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Seger, R Weizmann Inst Sci, Dept Regulat Biol, IL-71600 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-71600 71600 Rehovot, Israel
Citazione:
R. Seger et al., "The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis", J BIOL CHEM, 276(17), 2001, pp. 13957-13964

Abstract

The response of granulosa cells to luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is mediated mainly by cAMP/protein kinase A (PKA) signaling. Notably, the activity of the extracellular signal-regulated kinase (ERK) signaling cascade is elevated in response to these stimuli as well. We studied the involvement of the ERK cascade in LH- and FSH-induced steroidogenesis in two granulosa derived cell lines, rLHR-4 and rFSHR-17, respectively. We found that stimulation of these cells with the appropriate gonadotropin induced ERK activation as well as progesterone production downstream of PKA. Inhibition of ERR activity enhanced gonadotropin-stimulated progesterone production, which was correlated with increased expression of the steroidogenic acute regulatory protein (StAR), a key regulator of progesterone synthesis. Therefore, it is likely that gonadotropin-stimulated progesterone formation is regulated by a pathway that includes PKA and StAR, and this process is down-regulated by ERK, due to attenuation of StAR expression. Our results suggest that activation of PKA signaling by gonadotropins notonly induces steroidogenesis but also activates down-regulation machinery involving the ERR cascade. The activation of ERK by gonadotropins as well as by other agents may be a key mechanism for the modulation of gonadotropin-induced steroidogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 14:53:33