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Titolo:
Threshold levels of maternal nicotine impairing protective responses of newborn rats to intermittent hypoxia
Autore:
Fewell, JE; Smith, FG; Ng, VKY;
Indirizzi:
Univ Calgary, Hlth Sci Ctr, Dept Physiol & Biophys, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 ophys, Calgary, AB T2N 4N1, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1968 - 1976
SICI:
8750-7587(200105)90:5<1968:TLOMNI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFANT-DEATH-SYNDROME; CIGARETTE-SMOKING; EXPOSURE; PREGNANCY; APNEA; AUTORESUSCITATION; FETAL; SLEEP; EPIDEMIOLOGY; INFUSIONS;
Keywords:
apnea; hypoxic gasping; perinatal drug exposure; sudden infant death syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Fewell, JE Univ Calgary, Hlth Sci Ctr, Dept Physiol & Biophys, Heritage Med Res Bldg 206,3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada Univ Calgary Heritage Med Res Bldg 206,3330 Hosp Dr NW Calgary AB Canada T2N 4N1
Citazione:
J.E. Fewell et al., "Threshold levels of maternal nicotine impairing protective responses of newborn rats to intermittent hypoxia", J APP PHYSL, 90(5), 2001, pp. 1968-1976

Abstract

Experiments were carried out to determine the threshold level of maternal nicotine that impairs protective responses of rat pups to hypoxia. From days 6 or 7 of gestation, pregnant rats received either vehicle or nicotine (1.50, 3.00, or 6.00 mg of nicotine tartrate.kg body wt(-1).day(-1)) or vehicle continuously via a subcutaneous osmotic minipump. On postnatal days 5 or6, pups were exposed to a single period of hypoxia produced by breathing an anoxic gas mixture (97% N-2 or 3% CO2) and their time to last gasp was determined, or they were exposed to intermittent hypoxia and their ability toautoresuscitate from hypoxic-induced primary apnea was determined. Perinatal exposure to nicotine did not alter the time to last gasp or the total number of gasps when the pups were exposed to a single period of hypoxia. Thenumber of successful autoresuscitations on repeated exposure to hypoxia was, however, decreased in pups whose dams had received either 3.00 or 6.00 mg of nicotine tartrate/kg body wt; these dosage regimens produced maternal serum nicotine concentrations of 19 +/- 6 and 35 +/- 8 ng/ml, respectively. Thus our experiments define the threshold level of maternal nicotine that significantly impairs protective responses of 5- to 6-day-old rat pups to intermittent hypoxia such as may occur in human infants during episodes of prolonged sleep apnea or positional asphyxia.

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Documento generato il 28/01/20 alle ore 14:43:19