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Titolo:
A rat lung model of instilled liquid transport in the pulmonary airways
Autore:
Cassidy, KJ; Bull, JL; Glucksberg, MR; Dawson, CA; Haworth, ST; Hirschl, R; Gavriely, N; Grotberg, JB;
Indirizzi:
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Biomed Engn, Ann Arbor, MI 48109 USA Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Mech Engn, Evanston, IL 60208 USA Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 omed Engn, Evanston, IL 60208 USA Marquette Univ, Milwaukee, WI 53233 USA Marquette Univ Milwaukee WI USA 53233 uette Univ, Milwaukee, WI 53233 USA Med Coll Wisconsin, Milwaukee, WI 53201 USA Med Coll Wisconsin Milwaukee WI USA 53201 consin, Milwaukee, WI 53201 USA Zablocki Vet Adm Med Ctr, Milwaukee, WI 53295 USA Zablocki Vet Adm Med Ctr Milwaukee WI USA 53295 , Milwaukee, WI 53295 USA Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 , Dept Surg, Ann Arbor, MI 48109 USA Technion Israel Inst Technol, Dept Physiol, Haifa, Israel Technion Israel Inst Technol Haifa Israel , Dept Physiol, Haifa, Israel
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1955 - 1967
SICI:
8750-7587(200105)90:5<1955:ARLMOI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; END-EXPIRATORY PRESSURE; HIGH-FREQUENCY JET; SURFACTANT REPLACEMENT; EXOGENOUS SURFACTANT; SYNTHETIC SURFACTANT; SMOKE-INHALATION; GENE-TRANSFER; VENTILATION; THERAPY;
Keywords:
surfactant replacement therapy; respiratory distress syndrome; liquid ventilation; drug delivery; exogenous lung surfactant; liquid bolus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Grotberg, JB Univ Michigan, Dept Biomed Engn, 3304 GG Brown Bldg,2350 Hayward St, Ann Arbor, MI 48109 USA Univ Michigan 3304 GG Brown Bldg,2350 Hayward St Ann Arbor MI USA 48109
Citazione:
K.J. Cassidy et al., "A rat lung model of instilled liquid transport in the pulmonary airways", J APP PHYSL, 90(5), 2001, pp. 1955-1967

Abstract

When a liquid is instilled in the pulmonary airways during medical therapy, the method of instillation affects the liquid distribution throughout thelung. To investigate the fluid transport dynamics, exogenous surfactant (Survanta) mixed with a radiopaque tracer is instilled into tracheae of vertical, excised rat lungs (ventilation 40 breaths/min, 4 ml tidal volume). Twomethods are compared: For case A, the liquid drains by gravity into the upper airways followed by inspiration; for case B, the liquid initially formsa plug in the trachea, followed by inspiration. Experiments are continuously recorded using a microfocal X-ray source and an image-intensifier, charge-coupled device image train. Video images recorded at 30 images/s are digitized and analyzed. Transport dynamics during the first few breaths are quantified statistically and follow trends for liquid plug propagation theory. A plug of liquid driven by forced air can reach alveolar regions within the first few breaths. Homogeneity of distribution measured at end inspiration for several breaths demonstrates that case B is twice as homogeneous as case A. The formation of a liquid plug in the trachea, before inspiration, is important in creating a more uniform liquid distribution throughout the lungs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:47:34