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Titolo:
Intracellular signaling specificity in skeletal muscle in response to different modes of exercise
Autore:
Nader, GA; Esser, KA;
Indirizzi:
Univ Illinois, Sch Kinesiol, Muscle Biol Lab, Chicago, IL 60608 USA Univ Illinois Chicago IL USA 60608 Muscle Biol Lab, Chicago, IL 60608 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1936 - 1942
SICI:
8750-7587(200105)90:5<1936:ISSISM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-B; GLYCOGEN-SYNTHASE KINASE-3; S6 KINASE; BIOCHEMICAL ADAPTATIONS; RESISTANCE EXERCISE; MAMMALIAN TARGET; MESSENGER-RNA; CYTOCHROME-C; MAP KINASE; INSULIN;
Keywords:
hypertrophy; endurance; signal transduction; adaptation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Esser, KA Univ Illinois, Sch Kinesiol, Muscle Biol Lab, M-C 194,901 W Roosevelt Rd, Chicago, IL 60608 USA Univ Illinois M-C 194,901 W Roosevelt Rd Chicago IL USA 60608 SA
Citazione:
G.A. Nader e K.A. Esser, "Intracellular signaling specificity in skeletal muscle in response to different modes of exercise", J APP PHYSL, 90(5), 2001, pp. 1936-1942

Abstract

The aim of this study was to understand better the specific signaling events resulting from different modes of exercise. Three different exercise protocols were employed based on their well-characterized, long-term training effects on either muscle hypertrophy or endurance phenotypes. Rats were subjected to a single bout of either a high-frequency electrical stimulation, a low-frequency electrical stimulation, or a running exercise protocol. Postexercise intracellular signaling was analyzed in the tibialis anterior andsoleus muscles at 0, 3, and 6 h. A prolonged increase in p70(S6k) and a transient increase in protein kinase B phosphorylation were only observed in response to a growth-inducing stimulus (e.g., tibialis anterior in high-frequency electrical stimulation). In contrast, extracellular regulated kinaseand 38-kDa stress-activated protein kinase were activated in response to all forms of exercise at 0 h, but only extracellular regulated kinase phosphorylation was found significantly elevated at 6 h after running exercise. These results demonstrate that different exercise protocols resulted in the selective activation of specific intracellular signaling pathways, which may determine the specific adaptations induced by different forms of exercise.

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Documento generato il 29/09/20 alle ore 08:56:59