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Titolo:
Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse
Autore:
Allen, DL; Harrison, BC; Maass, A; Bell, ML; Byrnes, WC; Leinwand, LA;
Indirizzi:
Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 ular & Dev Biol, Boulder, CO 80309 USA Univ Colorado, Dept Kinesiol, Boulder, CO 80309 USA Univ Colorado BoulderCO USA 80309 , Dept Kinesiol, Boulder, CO 80309 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1900 - 1908
SICI:
8750-7587(200105)90:5<1900:CASMAT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-HOUSE MICE; PEPTIDE GENE-EXPRESSION; ENDURANCE EXERCISE; ADAPTIVE RESPONSE; RAT MYOCARDIUM; SOLEUS; TREADMILL; SELECTION; HYPERTROPHY; INTENSITY;
Keywords:
myosin heavy chain; endurance exercise; plasticity; cardiac hypertrophy; transgenic mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Leinwand, LA Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 ol, Boulder, CO 80309 USA
Citazione:
D.L. Allen et al., "Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse", J APP PHYSL, 90(5), 2001, pp. 1900-1908

Abstract

In this paper, we describe the effects of voluntary cage wheel exercise onmouse cardiac and skeletal muscle. Inbred male C57/B16 mice (age 8-10 wk; n = 12) ran an average of 4.3 h/24 h, for an average distance of 6.8 km/24 h, and at an average speed of 26.4 m/min. A significant increase in the ratio of heart mass to body mass (mg/g) was evident after 2 wk of voluntary exercise, and cardiac atrial natriuretic factor and brain natriuretic peptidemRNA levels were significantly increased in the ventricles after 4 wk of voluntary exercise. A significant increase in the percentage of fibers expressing myosin heavy chain (MHC) IIa was observed in both the gastrocnemius and the tibialis anterior (TA) by 2 wk, and a significant decrease in the percentage of fibers expressing IIb MHC was evident in both muscles after 4 wk of voluntary exercise. The TA muscle showed a greater increase in the percentage of IIa MHC-expressing fibers than did the gastrocnemius muscle (40 and 20%, respectively, compared with 10% for nonexercised). Finally, the number of oxidative fibers as revealed by NADH-tetrazolium reductase histochemical staining was increased in the TA but not the gastrocnemius after 4 wkof voluntary exercise. All results are relative to age-matched mice housedwithout access to running wheels. Together these data demonstrate that voluntary exercise in mice results in cardiac and skeletal muscle adaptations consistent with endurance exercise.

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Documento generato il 25/01/20 alle ore 16:08:56