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Titolo:
Reflex control of the cutaneous circulation after acute and chronic local capsaicin
Autore:
Charkoudian, N; Fromy, B; Saumet, JL;
Indirizzi:
Univ Angers, Lab Physiol & Explorat Fonctionnelles Vasc, F-49045 Angers, France Univ Angers Angers France F-49045 ionnelles Vasc, F-49045 Angers, France
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1860 - 1864
SICI:
8750-7587(200105)90:5<1860:RCOTCC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN FOREARM SKIN; REACTIVE HYPEREMIA; NITRIC-OXIDE; BLOOD-FLOW; VASODILATION; TEMPERATURE; RESPONSES; SMOKERS; NERVES;
Keywords:
regional blood flow; skin; vasodilation; laser-Doppler flowmetry; body temperature regulation; afferent neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Charkoudian, N Mayo Clin & Mayo Fdn, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 A
Citazione:
N. Charkoudian et al., "Reflex control of the cutaneous circulation after acute and chronic local capsaicin", J APP PHYSL, 90(5), 2001, pp. 1860-1864

Abstract

To investigate whether local activity of capsaicin-sensitive sensory afferents in the skin has a modulatory role in the reflex cutaneous vasodilator response to hyperthermia in humans, experiments were conducted in two parts. First, low-dose topical capsaicin (0.025%) was administered acutely to stimulate local activity of these afferents. Second, we temporarily desensitized these nerves in a small area of skin using chronic capsaicin treatment (0.075% for 7 days). Each intervention was followed by whole body heating using water-perfused suits and then by local warming to 42 degreesC for assessment of maximum cutaneous vascular conductance. Skin blood flow was measured by laser-Doppler flowmetry and divided by mean arterial pressure (Finapres) for assessment of cutaneous vascular conductance. Maximum vascular conductance was not influenced by either acute or chronic capsaicin treatment (P > 0.10). After acute capsaicin, baseline cutaneous vascular conductance was elevated above that at control sites (25.34 +/- 6.25 vs. 10.57 +/- 2.42% max; P < 0.05). However, internal temperature thresholds for vasodilationwere not affected by either acute or chronic capsaicin (P > 0.10). Furthermore, neither acute (control: 112.74 +/- 36.83 vs. acute capsaicin: 96.92 +/- 28.92% max/degreesC; P > 0.10) nor chronic (control: 142.45 +/- 61.89 vs. chronic capsaicin: 132.12 +/- 52.60% max/degreesC; P > 0.10) capsaicin administration influenced the sensitivity of the reflex cutaneous vasodilatorresponse. We conclude that local activity of capsaicin-sensitive afferentsin the skin does not modify reflex cutaneous vasodilation during hyperthermia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:28:35