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Titolo:
Myosin thick filament lability induced by mechanical strain in airway smooth muscle
Autore:
Kuo, KH; Wang, L; Pare, PD; Ford, LE; Seow, CY;
Indirizzi:
Univ British Columbia, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada Univ British Columbia, Dept Anat, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada Univ British Columbia, St Pauls Hosp, Pulm Res Lab, Vancouver, BC V6Z 1Y6,Canada Univ British Columbia Vancouver BC Canada V6Z 1Y6 uver, BC V6Z 1Y6,Canada Indiana Univ, Krannert Inst Cardiol, Indianapolis, IN 46220 USA Indiana Univ Indianapolis IN USA 46220 ardiol, Indianapolis, IN 46220 USA Univ British Columbia, St Pauls Hosp, Dept Pathol & Lab Med, Vancouver, BCV6Z 1Y6, Canada Univ British Columbia Vancouver BC Canada V6Z 1Y6 uver, BCV6Z 1Y6, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1811 - 1816
SICI:
8750-7587(200105)90:5<1811:MTFLIB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANOCOCCYGEUS; CONTRACTION; RAT; PLASTICITY; REST;
Keywords:
swine trachea; mechanics; length perturbation; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Seow, CY Univ British Columbia, Dept Pharmacol & Therapeut, 2176 Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada Univ British Columbia 2176 Hlth Sci Mall Vancouver BC Canada V6T 1Z3
Citazione:
K.H. Kuo et al., "Myosin thick filament lability induced by mechanical strain in airway smooth muscle", J APP PHYSL, 90(5), 2001, pp. 1811-1816

Abstract

Airway smooth muscle adapts to different lengths with functional changes that suggest plastic alterations in the filament lattice. To look for structural changes that might be associated with this plasticity, we studied the relationship between isometric force generation and myosin thick filament density in cell cross sections, measured by electron microscope, after length oscillations applied to the relaxed porcine trachealis muscle. Muscles were stimulated regularly for 12 s every 5 min. Between two stimulations, themuscles were submitted to repeated passive +/-30% length changes. This caused tetanic force and thick-filament density to fall by 21 and 27%, respectively. However, in subsequent tetani, both force and filament density recovered to preoscillation levels. These findings indicate that thick filamentsin airway smooth muscle are labile, depolymerization of the myosin filaments can be induced by mechanical strain, and repolymerization of the thick filaments underlies force recovery after the oscillation. This thick-filament lability would greatly facilitate plastic changes of lattice length and explain why airway smooth muscle is able to function over a large length range.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:43:22