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Titolo:
Detergent inhibits 70-90% of responses to intravenous endotoxin in awake sheep
Autore:
Staub, NC; Longworth, KE; Serikov, V; Jerome, EH; Elsasser, T;
Indirizzi:
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif Davis, Sch Vet Med, Davis, CA 95616 USA Univ Calif Davis DavisCA USA 95616 vis, Sch Vet Med, Davis, CA 95616 USA USDA, Beltsville, MD 20705 USA USDA Beltsville MD USA 20705USDA, Beltsville, MD 20705 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1788 - 1797
SICI:
8750-7587(200105)90:5<1788:DI7ORT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY INTRAVASCULAR MACROPHAGES; TUMOR-NECROSIS-FACTOR; ACUTE LUNG INJURY; ANESTHETIZED SHEEP; MECHANISMS; ENDOCYTOSIS; DEPLETION; EFFICACY; NEWBORN; BINDING;
Keywords:
systemic inflammatory response syndrome; septicemia; acute lung injury; lung lymph protein clearance; sheep tumor necrosis factor; leukocyte sequestration; tyloxapol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Staub, NC Box 965, Stinson Beach, CA 94970 USA Box 965 Stinson Beach CA USA 94970 Stinson Beach, CA 94970 USA
Citazione:
N.C. Staub et al., "Detergent inhibits 70-90% of responses to intravenous endotoxin in awake sheep", J APP PHYSL, 90(5), 2001, pp. 1788-1797

Abstract

Sheep have reactive pulmonary intravascular macrophages, which are essential for the marked pulmonary vascular response to infusions of small quantities of endotoxin. In another species with reactive pulmonary intravascular macrophages, horses, our laboratory found that an intravenous biosafe detergent, tyloxapol, inhibited some systemic and pulmonary responses to endotoxin (Longworth KE, Smith BL, Staub NC, Steffey EP, and Serikov V. Am J Vet Res 57: 1063-1066, 1996). We determined whether the same detergent would inhibit endotoxin responses in awake sheep. In 10 awake, instrumented sheep with chronic lung lymph fistulas, we did a control experiment by intravenously infusing 1 mug/kg Escherichia coli endotoxin. One week later, we gave 40 mu mol/kg tyloxapol intravenously 1-4 h before infusing the same dose of endotoxin. In these paired studies, we compared pulmonary hemodynamics, lung lymph dynamics, body temperature, circulating leukocyte concentrations, andcirculating tumor necrosis factor for 6 h. In all 10 sheep, tyloxapol blocked 80-90% of the pulmonary responses and 70-90% of the systemic responses. Tyloxapol is safe, inexpensive, easy to use, and effective immediately. Itmay be a clinically useful approach to contravening many of the effects ofendotoxemia, in humans as well as animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:49:52