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Titolo:
Saline aerosol bolus dispersion. I. The effect of acinar airway alteration
Autore:
Verbanck, S; Schuermans, DL; Vincken, W; Paiva, M;
Indirizzi:
Free Univ Brussels, Acad Hosp, Div Resp, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 esp, B-1090 Brussels, Belgium Free Univ Brussels, Lab Phys Biomed, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 med, B-1070 Brussels, Belgium
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1754 - 1762
SICI:
8750-7587(200105)90:5<1754:SABDIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LUNG; REGIONAL DEPOSITION; VENTILATION; INHOMOGENEITY; SIMULATIONS; TRANSPORT; BEHAVIOR; VOLUME;
Keywords:
N-2 washout; smokers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Verbanck, S AZ VUB, Consultatie Pneumol, Laarbeeklaan 101, B-1090 Brussels, Belgium AZ VUB Laarbeeklaan 101 Brussels Belgium B-1090 sels, Belgium
Citazione:
S. Verbanck et al., "Saline aerosol bolus dispersion. I. The effect of acinar airway alteration", J APP PHYSL, 90(5), 2001, pp. 1754-1762

Abstract

We explored the possibility of using a saline aerosol for bolus dispersionmeasurements to detect peripheral airway alterations in smokers. Indexes of ventilation inhomogeneity in conductive (S-cond) and acinar (S-acin) lungzones, as derived from the multiple-breath N-2 washout (Verbanck S, Schuermans D, Van Muylem A, Noppen M, Paiva M, and Vincken W, J Appl Physiol 83: 1807-1816, 1997), were also measured. The saline bolus test consisted of inhaling 60-ml saline aerosol boluses to different volumetric lung depths (VLD) in the 1.1 liter volume above functional residual capacity. In the never-smoker group (n = 12), saline boluses showed bolus dispersion values consistent with normal values reported in the literature for 0.5- to 1-mum aerosols. In the smoker group (n = 12; 28 +/- 9 pack years, mean +/- SD), significant increases were seen on dispersion and skew of the most peripherally inhaled saline boluses (VLD = 800 ml; P < 0.05) as well as on S-acin (P = 0.007) with respect to never-smokers. Shallow inhaled boluses (VLD = 200 ml) and S-cond did not reveal any significant differences between smokers and never-smokers. This study shows the consistent response of two conceptually independent tests, in which both saline aerosol and gas-derived indexes point to a heterogeneous distribution of smoking-induced structural alterations in the lung periphery.

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Documento generato il 02/04/20 alle ore 01:55:17